Cowherb (Vaccaria segetalis), also known as Wang Bu Liu Xing in traditional Chinese medicine (TCM), has a long history of use in East Asian herbal practice. Its traditional indications primarily include promoting lactation, invigorating blood circulation, and treating certain gynecological disorders. In some classical and folk medicinal texts, cowherb has also been mentioned as part of broader herbal formulations used to address acute diarrhea and symptoms reminiscent of cholera. The rationale for its use is based on the TCM principle of "clearing heat" and "removing toxicity", which are believed to underlie some gastrointestinal infections.

However, the specific application of cowherb for cholera (an acute diarrheal disease caused by Vibrio cholerae) is not prominent in the major TCM materia medica or modern clinical TCM guidelines. Its role, when mentioned, is usually as a minor ingredient within multi-herb formulas rather than as a primary remedy. Scientific literature provides little direct evidence of efficacy against cholera or its causative organism. Few, if any, pharmacological studies have investigated cowherb for anti-diarrheal or antimicrobial effects relevant to cholera.

Therefore, cowherb's use in cholera is supported primarily by traditional practice and historical anecdote, with weak or indirect evidence. It is not recommended as a substitute for proven cholera treatments such as oral rehydration therapy and antibiotics.