Evidence supporting the use of: Holarrhena (unspecified)
For the health condition: Cholera

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Holarrhena, particularly Holarrhena antidysenterica (also known as Kutaja or Kurchi), has a long history of use in traditional medicine systems such as Ayurveda and Unani for the treatment of gastrointestinal disorders, including diarrhea and dysentery. Its use in supporting or treating cholera is primarily justified on traditional grounds rather than robust scientific validation. Historical texts and ethnobotanical surveys cite the use of Holarrhena bark and seeds in formulations to manage severe diarrhea and dehydration associated with cholera. The plant contains alkaloids such as conessine, which have demonstrated some antibacterial activity in vitro, and may contribute to its perceived efficacy. However, modern clinical trials specifically evaluating its effectiveness against cholera (caused by Vibrio cholerae) are lacking or very limited. Most available research focuses on its antidiarrheal and antimicrobial properties in general, and not specifically on cholera. Therefore, while traditional use is well-documented, the scientific evidence supporting its efficacy for cholera is weak and not conclusive. Its use persists in some herbal practices, but it should not be considered a substitute for proven medical treatments for cholera.

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