Synopsis

Source of validity: Traditional
Rating (out of 5): 1

The use of indigo leaves (Indigofera tinctoria) for treating cholera is primarily rooted in traditional medicine, especially in some South Asian and African communities. Traditional healers have employed preparations of indigo leaves as remedies for a variety of gastrointestinal ailments, including diarrhea and dysentery, which are symptoms commonly associated with cholera. Historical texts and ethnobotanical surveys often mention the use of indigo leaf juices or decoctions for their supposed antimicrobial and anti-inflammatory properties, which could theoretically provide symptomatic relief during episodes of cholera. However, these uses are based on anecdotal evidence, traditional beliefs, and empirical practices rather than rigorous scientific validation.

There is limited scientific research regarding the efficacy of indigo leaves specifically against Vibrio cholerae, the bacterium responsible for cholera. While some laboratory studies have identified general antimicrobial or antioxidant properties in extracts of indigo leaves, none have demonstrated clear or direct anti-cholera activity, nor have controlled clinical trials validated its clinical use for this condition. As a result, the rating of evidence supporting indigo leaves for cholera treatment is very low. Modern medical management of cholera relies on oral rehydration therapy and antibiotics, and there is no recognized place for indigo leaf preparations in contemporary evidence-based medicine for cholera. Use of such remedies should be approached with caution and not as a substitute for proven therapies.

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