Lodhtree (Symplocos racemosa), commonly known as Lodhra, has a long history of use in traditional Ayurvedic and Unani medicine. Its bark and preparations are traditionally used for a variety of ailments, primarily gynecological, bleeding disorders, and as an astringent. In some traditional texts and ethnobotanical surveys, Lodhtree is mentioned as an ingredient in polyherbal formulations for managing gastrointestinal disturbances, including diarrhea and dysentery, which are symptoms sometimes associated with cholera. However, there is limited specific reference to its direct use for cholera itself in classical Ayurvedic literature.

Scientific validation for its effectiveness against cholera or Vibrio cholerae is currently lacking. While some in vitro studies have noted antibacterial properties of Lodhra extracts against various pathogens, clinical or robust experimental evidence for its efficacy against cholera is absent. The use of Lodhtree for cholera is thus primarily based on tradition, likely rooted in its general astringent and antimicrobial properties valued in folk medicine for treating diarrhea. Overall, the direct evidence for its use in cholera is weak, and it should not be considered a proven treatment for this disease.