Evidence supporting the use of: Tannin (unspecified)
For the health condition: Cholera

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Tannins, a group of polyphenolic compounds found in various plants, have a long history of traditional use for treating diarrhea and gastrointestinal disturbances, including cholera. Historically, tannin-rich extracts from plants such as oak bark, witch hazel, and others were utilized in folk medicine as astringents to reduce intestinal inflammation and fluid secretion. In the context of cholera, which is characterized by severe watery diarrhea, tannins were believed to help by “astringing” the gut lining and reducing fluid loss.

There is some limited scientific rationale for this traditional use: tannins can precipitate proteins and form a protective layer on mucous membranes, potentially reducing irritation and fluid exudation. Additionally, some studies have shown tannins possess antimicrobial properties against certain pathogens. However, direct, high-quality clinical evidence supporting the effectiveness of tannins specifically for cholera is lacking. Most available studies are either in vitro, animal studies, or small, non-controlled human reports. Modern cholera management relies on rehydration therapy and antibiotics, not tannins.

In summary, while the use of tannins for cholera is rooted in traditional practices and there is a plausible mechanism of action, robust scientific validation is lacking. Their role in contemporary treatment of cholera is minimal and not recommended by current medical guidelines.

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