Synopsis

Source of validity: Traditional
Rating (out of 5): 1

Xanthium (commonly known as cocklebur) has a history of use in traditional medicine, particularly within Chinese and Ayurvedic systems. In traditional Chinese medicine (TCM), Xanthium sibiricum (Cang Er Zi) is most often used to treat nasal congestion, headaches, and certain skin conditions; however, there are occasional mentions in ethnobotanical texts of its use for gastrointestinal issues, including diarrhea and dysentery, which are symptoms that can occur in cholera. Some folk traditions in India and other countries have also reported the use of cocklebur preparations for similar symptoms. Despite these historical uses, there is little to no robust scientific evidence supporting the effectiveness of Xanthium specifically for treating cholera, a severe diarrheal disease caused by Vibrio cholerae. No clinical trials or pharmacological studies directly demonstrate benefit in cholera treatment. Furthermore, Xanthium contains toxic compounds (notably carboxyatractyloside) that can cause severe poisoning if not properly processed. Therefore, while its use may be justified by tradition in some cultures, the overall evidence is weak (rated 1/5), and significant safety concerns exist. Modern medical guidance does not recommend Xanthium for cholera, and it should not be used as a substitute for established treatments such as oral rehydration therapy and antibiotics.

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