Evidence supporting the use of: Blueberry
For the health condition: Cholesterol (high)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Blueberry (Vaccinium spp.) has been studied for its potential effects on cholesterol levels and cardiovascular health. The fruit is rich in polyphenols, particularly anthocyanins, which are thought to have beneficial effects on lipid metabolism. Several small human clinical trials and animal studies have evaluated the impact of blueberry consumption on lipid profiles. Some studies show that regular blueberry intake can modestly reduce LDL ("bad") cholesterol and increase HDL ("good") cholesterol, as well as improve other markers of cardiovascular risk, such as oxidative stress and inflammation.

For example, a randomized controlled trial published in the American Journal of Clinical Nutrition (2019) found that daily consumption of freeze-dried blueberries improved endothelial function and reduced LDL cholesterol in adults with metabolic syndrome. Animal studies have demonstrated similar benefits, showing reduced cholesterol absorption and improved lipid metabolism after blueberry supplementation.

However, not all studies have found significant improvements in cholesterol levels, and the effects observed are generally modest. The evidence base is growing but still limited by small sample sizes, short durations, and variability in blueberry preparations. Thus, while there is a scientific rationale and some clinical validation for the use of blueberries in supporting healthy cholesterol levels, they should not be considered a replacement for established treatments. Instead, they may be a helpful adjunct to a heart-healthy diet.

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Acacia
Acai berry
Adzuki bean
Aegeline
Ajoene
Akkermansia muciniphila
Alcohol
Alfalfa
Algae
algal oil
Algal protein
Allicin
Alliin
Allium tuberosum
Almond fruit
Alpha methyl tetradecylthioacetic acid
Alpha phytosterol
alpha-linolenic acid (ALA)
alpha-lipoic acid
alpinia galangal
amaranth
AMP-activated protein kinase (AMPK)
ampelopsin
andrographolide
Angelica
ankaflavin
anthocyanidins
anthocyanins
Antrodia camphorata
apple
apple cider vinegar
arabinoxylan
argan nut oil
arjun tree
arjuna
arjunic acid
Arjunolic acid
Aronia melanocarpa
artichoke
Ascophyllum nodosum
ashitaba
ashwagandha
Aspergillus
astaxanthin
astragalin
astragaloside
astragalus
atractylodes
Auricularia
avocado
Bacillus
bacillus coagulans
bacillus subtilis
bacoside
bacteria
bael
baicalein
banaba
baobab
barberry
barley
Basidiomycota
basil
Bassia scoparia
Bauhinia
bayleaf
bean
bee pollen
bee products
beet
berberine
Berberis (unspecified)
bergamot
beta-glucan
beta-sitosterol
Bifidobacteria
Bifidobacterium
Bifidobacterium animalis
Bifidobacterium bifidum
Bifidobacterium lactis
Bifidobacterium longum
bignay
bile acid
biochanin
birch
bishop\'s weed
bitter grass
black cumin
black currant
black galingale
black garlic
black ginger
black seed
black tea
blackberry
Blue-Green Alage
blueberry
Boerhavia diffusa
Bombax
bonito peptide
bottle gourd
bran
Brassica
Brazil nut
breadnut
broccoli
Brown Algae
Brussel sprouts
brutieridin
Buckwheat
burdock
bасора
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cabbage
cactus
Caesalpinia crista
calamari oil
Calanus finmarchicus
California chia
camelina oil
Camellia sinensis
campestanol
campesterol
capillary artemisia
capsinoids
cardarine
carnosic acid
carob
carqueja
carrot
cashew
cassia bark
catechins
caterpillar mushroom
cauliflower
celery
cereal grass
champignon
charantin
chebulic acid
chia seed
chia seed
chickpea protein
chicory
Chinese fleeceflower
Chinese Ligustrum berry
Chinese salvia root
Chinese silkvine
chitin
Chitin-Glucan Complex
chitosan
chlorella
chlorogenic acid
chokeberry
Chordaria cladosiphon
cinnamaldehyde
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Clostridium butyricum
cloudberry
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cod liver oil
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cyanidin
cyanobacteria
Cyclanthera pedata
cynarin
daidzein
dandelion
danshen
date
dextrin
DHA (docosahexaenoic acid)
diacylglycerol
diallyl disulfide (DADS)
diallyl sulfide
diallyl trisulfide (DATS)
dioscorea
diterpenes
docosahexaenoic Acid
DPA (docosapentaenoic acid)
dragon fruit
Dumontiaceae
Dunaliella
Echium
Ecklonia
eggplant
eicosapentaenoic acid
emblicanin
endive
enokitake
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
equol (proprietary)
eriocitrin
erythrodiol
Eucheuma
Eucommia ulmoides
Euglena gracilis
Fagopyrum
false flax
fatty acids
fenugreek
ferulic acid
fiber
fiber blend (proprietary)
fig
fish
fish oil
fish protein
Flammulina velutipes
flavanols
flavanones
flavans
flavones
flavonoids
flavonols
flavonones
flaxseed
fo-ti
Foxtail millet
fructooligosaccharides (FOS)
fruit
fruit and vegetable blend (proprietary)
fucoidan
fucosterol
fucoxanthin
fungus
galactomannan
galactooligosaccharides
gallate
gallic acid
gamma oryzanol
ganoderma
garbanzo bean
garcinia
garden cress
garlic
garlic bulb
genistein
genistin
ginger
ginseng
Ginsenosides
Glucan peptides
glucomannan
Glucoraphanin
goji berry
gooseberry
grape
grapefruit
Greek mountain tea
green chiretta
green tea
greens blend (proprietary)
guar gum
Guava
Gugglesterone
guggul
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gum
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Gymnema sylvestre
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Haematococcus pluvialis
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hemicellulose
hemp oil
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hesperetin
hesperidin
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horse gram
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hydroxyphenylethanols
hydroxytyrosol
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hypsizygus marmoreus
Ilex
Indian bael
Indian kinotree
Indian tinospora
inositol nicotinate
inulin
Irvingia gabonensis
isoflavones
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Java tea
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jujube
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kale
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l-carnitine
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lactiplantibacillus plantarum
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Laver
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Lentil
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Lessonia
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limonoid
lingonberry
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lotus
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lycopene
macadamia
magnesium
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Matcha
Mate
medium chain triglycerides (MCT)
Methoxylated flavones
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millet seed
Momordica
Momordicosides
Monacolin
Monounsaturated fat
Morinda
Moringa
Morus
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mustard seed
Myricetin
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Neem tree
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Niacinamide (vitamin B3)
nicotinamide riboside
Nigella seed
Nobiletin
Nomilin
noni
nopal
Nori
nut grass
oat
Octacosanol
oleanolic acid
oleic acid
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Oligomeric proanthocyanidins
Oligosaccharides
olive
omega-3 fatty acids
omega-6 fatty acids
omega-7 fatty acids
omega-9 fatty acids
onion
oolong tea
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orange
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oyster mushroom
palmitoleic acid
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phospholipids
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pine bark
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Plankton
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policosanol
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poly-thyronine
Polydatin
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Polygonum
polymethoxylated flavones
polyphenols
polysaccharides
polyunsaturated fat
pomegranate
pomelo
prebiotic blend (proprietary)
Prickly Pear Cactus
proanthocyanidins
procyanidin
Propionibacterium freudenreichii
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prune
psyllium
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pu-er tea
Puerain
Puerarin
pumpkin
punarnava
punicalagins
punicic acid
purple tea
purslane
Pycnogenol
quercetin
quinoa
Quinoa Protein
radish
rapeseed oil
raspberry
red clover
red yeast
red yeast rice
reishi mushroom
resin
resveratrol
rhizome
Rhizopus oryzae
rhubarb
rice
Rooibos
root tuber
Rosa roxburghii
rose hips
rosemary
royal jelly
rutin
rye
S-allylcysteine
Saccharomyces cerevisiae
Sacha Inchi
safflower oil
Salacia
Salba Oil
Salmon Oil
Salvianolic acid
Sapogenin
saponins
Schizochytrium
Schizochytrium Oil
Scoparia dulcis
seaweed
secoisolariciresinol diglucoside
sesame
Sesamin
Sesamolin
Sete sangrias
shiitake mushroom
Shilajit
Shogaol
Sichuan Lovage
sitostanol
Sitosterol
Solanum anguivi
soursop
Soy
soy isoflavones
Soy Protein
soybean
spinach
spirulina
Stearidonic acid
sterols
Stevioside
Stigmastanol
stigmasterol
Stilbenoid
strawberry
Sulfated polysaccharide
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Sumac
sunflower
Sunflower oil
Swertia
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Tinospora cordifolia
tocotrienols
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Tremella
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Triterpenes
turmeric
Varuna
vegetable and fruit blend (proprietary)
vegetable blend (proprietary)
vegetable oil
Vegetable Protein
Vine tea
vitamin C
Wakame
Walnut
Wasabi
Watermelon
Wax Gourd
wheat germ
wheat grass
Whey protein
White Tea
Withanolides
Xanthohumol
Xanthone
Xanthophyll
Xylaria nigripes
xylooligosaccharides
Yacon
Yeast
Yerba mate
Yumberry
Yuzu
zanthoxylum
Zedoary
Zingerone
Zucchini
β-nicotinamide mononucleotide (NMN)

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