Relationship: Cholesterol (high) and DHA (docosahexaeonic acid)

Evidence supporting the use of: DHA (docosahexaenoic acid)
For the health condition: Cholesterol (high)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Docosahexaenoic acid (DHA) is an omega-3 polyunsaturated fatty acid primarily found in fish oil. There is scientific evidence supporting the use of DHA, often alongside eicosapentaenoic acid (EPA), for modifying blood lipid profiles, including effects on cholesterol. Several randomized controlled trials and meta-analyses have shown that DHA supplementation can lower serum triglycerides, which are a type of blood lipid often elevated alongside cholesterol in dyslipidemia. However, the effect of DHA on LDL ("bad") cholesterol is more nuanced; some studies have reported that DHA may slightly increase LDL cholesterol while improving other lipid parameters, such as raising HDL ("good") cholesterol and reducing triglycerides.

The mechanism by which DHA affects cholesterol involves modulation of hepatic lipid metabolism, reduced very-low-density lipoprotein (VLDL) synthesis, and improved clearance of triglyceride-rich particles. The American Heart Association and other expert bodies recognize omega-3 fatty acids, including DHA, as beneficial for cardiovascular health, primarily through triglyceride reduction. However, for the specific goal of lowering high total or LDL cholesterol, the evidence is mixed, and DHA is generally not the first-line therapy for hypercholesterolemia—statins and lifestyle changes remain standard. Still, DHA can be a useful adjunct, especially in patients with mixed dyslipidemia or high triglycerides.

In summary, while DHA has a scientifically validated role in improving some aspects of lipid profiles, its direct effect on high cholesterol is modest, and the evidence for reducing LDL cholesterol is less robust than for reducing triglycerides.

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Products containing DHA (docosahexaenoic acid)

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Evidence supporting the use of: DHA (docosahexaenoic acid)
For the health condition: Cholesterol (high)

Table of Contents

Synopsis

Other ingredients used for Cholesterol (high)

Other health conditions supported by DHA (docosahexaenoic acid)

Products containing DHA (docosahexaenoic acid)

Health Concerns

Brands

Evidence supporting the use of: DHA (docosahexaenoic acid)For the health condition: Cholesterol (high)

Table of Contents

Synopsis

Other ingredients used for Cholesterol (high)

Other health conditions supported by DHA (docosahexaenoic acid)

Products containing DHA (docosahexaenoic acid)

Evidence supporting the use of: DHA (docosahexaenoic acid)
For the health condition: Cholesterol (high)