Relationship: Cholesterol (high) and niacin (vitamin B3)

Evidence supporting the use of: Niacin (vitamin B3)
For the health condition: Cholesterol (high)

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Synopsis
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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Niacin (vitamin B3) has substantial scientific evidence supporting its use in the management of high cholesterol. Niacin has been used since the 1950s as one of the first lipid-lowering agents. It works mainly by inhibiting hepatic synthesis of very-low-density lipoprotein (VLDL), which leads to decreased levels of low-density lipoprotein (LDL, “bad” cholesterol), and by raising high-density lipoprotein (HDL, “good” cholesterol) levels. Numerous clinical trials have demonstrated that niacin can lower total cholesterol, LDL, and triglycerides, while significantly increasing HDL cholesterol. Notably, the Coronary Drug Project (1975) and the HDL-Atherosclerosis Treatment Study (HATS, 2001) showed cardiovascular benefit in patients taking niacin, especially when used in combination with other lipid-lowering agents.

However, more recent large-scale trials, such as AIM-HIGH (2011) and HPS2-THRIVE (2014), found that while niacin does modify lipid profiles, it does not provide additional cardiovascular protection when added to statin therapy, and is associated with increased side effects (e.g., flushing, liver toxicity, insulin resistance). As a result, niacin is less commonly recommended as a first-line therapy today, but it is still sometimes used in patients who cannot tolerate statins or who need additional HDL-raising benefits. In summary, the use of niacin for high cholesterol has a strong scientific basis, but its role in current practice is limited by newer evidence regarding risks and benefits.

More about Niacin (vitamin B3)
More about Cholesterol (high)

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astragalus
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nicotinamide riboside
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zanthoxylum
Zedoary
Zingerone
Zucchini
β-nicotinamide mononucleotide (NMN)

Other health conditions supported by Niacin (vitamin B3)

Alcoholism
Arteriosclerosis
Burning Feet or Hands
Cholesterol (high)
Circulation (poor)
Fatty Liver Disease
Memory and Brain Function
Migraine
Schizophrenia
Triglycerides (high)

Products containing Niacin (vitamin B3)

Health Concerns

Brands

Evidence supporting the use of: Niacin (vitamin B3)
For the health condition: Cholesterol (high)

Table of Contents

Synopsis

Other ingredients used for Cholesterol (high)

Other health conditions supported by Niacin (vitamin B3)

Products containing Niacin (vitamin B3)

Health Concerns

Brands

Evidence supporting the use of: Niacin (vitamin B3)For the health condition: Cholesterol (high)

Table of Contents

Synopsis

Other ingredients used for Cholesterol (high)

Other health conditions supported by Niacin (vitamin B3)

Products containing Niacin (vitamin B3)

Evidence supporting the use of: Niacin (vitamin B3)
For the health condition: Cholesterol (high)