Relationship: Cholesterol (high) and niacin (vitamin B3)

Evidence supporting the use of: Niacin (vitamin B3)
For the health condition: Cholesterol (high)

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Synopsis
Other ingredients for this health condition
Other health conditions supported by this ingredient
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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Niacin (vitamin B3) has substantial scientific evidence supporting its use in the management of high cholesterol. Niacin has been used since the 1950s as one of the first lipid-lowering agents. It works mainly by inhibiting hepatic synthesis of very-low-density lipoprotein (VLDL), which leads to decreased levels of low-density lipoprotein (LDL, “bad” cholesterol), and by raising high-density lipoprotein (HDL, “good” cholesterol) levels. Numerous clinical trials have demonstrated that niacin can lower total cholesterol, LDL, and triglycerides, while significantly increasing HDL cholesterol. Notably, the Coronary Drug Project (1975) and the HDL-Atherosclerosis Treatment Study (HATS, 2001) showed cardiovascular benefit in patients taking niacin, especially when used in combination with other lipid-lowering agents.

However, more recent large-scale trials, such as AIM-HIGH (2011) and HPS2-THRIVE (2014), found that while niacin does modify lipid profiles, it does not provide additional cardiovascular protection when added to statin therapy, and is associated with increased side effects (e.g., flushing, liver toxicity, insulin resistance). As a result, niacin is less commonly recommended as a first-line therapy today, but it is still sometimes used in patients who cannot tolerate statins or who need additional HDL-raising benefits. In summary, the use of niacin for high cholesterol has a strong scientific basis, but its role in current practice is limited by newer evidence regarding risks and benefits.

More about niacin (vitamin B3)
More about Cholesterol (high)

Other ingredients used for Cholesterol (high)

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algal oil
alpha-linolenic acid (ALA)
green chiretta
anthocyanins
apple
arjun tree
artichoke
ashwagandha
astaxanthin
astragalus
bacillus coagulans
bacillus subtilis
banaba
barberry
barley
basil
beet
berberine
bergamot
berry flavor
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beta-sitosterol
bifidobacterium bifidum
bifidobacterium lactis
bifidobacterium longum
black cumin
black currant
black garlic
radish
sesame
black tea
blackberry
blueberry
bonito peptide
broccoli
rice
brussel sprouts
burdock
bасора
calamari oil
campesterol
canola oil
carrot
cassia bark
catechins
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chia seed
chicory
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chlorella
chokeberry
cinnamon
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citrus sinensis (proprietary)
clove
collard
conjugated linoleic acid (CLA)
cottonseed oil
cordyceps
turmeric
curcumin
dandelion
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diallyl disulfide (DADS)
diallyl trisulfide (DATS)
DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fenugreek
fiber blend (proprietary)
fish oil
fish protein
flavonols
flaxseed
fructooligosaccharides (FOS)
fruit and vegetable blend (proprietary)
gamma oryzanol
garcinia
garlic bulb
genistein
genistin
ginger
ginseng
glucomannan
gooseberry
grape
grapefruit
greek mountain tea
onion
green tea
greens blend (proprietary)
guar gum
guggul
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spirulina
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nomilin
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peanut
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Propolmannan
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Red Yeast
rhizopus oryzae
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Rosa Roxburghii
Rapeseed Oil
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Scoparia dulcis
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Solanum anguivi
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Shogaol
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Saccharomyces cerevisiae
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Stigmastanol
saponins
Sumac
Sesamolin
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Sunflower Oil
Shilajit
Stearidonic acid
Sacha Inchi
S-allylcysteine
Sesamin
Stilbenoid
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Terminalia
Tea
Tagatose
Thymoquinone
Tetradecylthioacetic acid
Thylakoid
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Thistle
Triterpenes
Tangeretin
Tejocote
Tanshinone
Taurine
Theaflavin
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Tamarind
Taraxacum
Theabrownin
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vegetable oil
Vinegar
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Vine tea
Varuna
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White Tea
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Xylaria nigripes
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Other health conditions supported by niacin (vitamin B3)

Alcoholism
Arteriosclerosis
Burning Feet or Hands
Cholesterol (high)
Circulation (poor)
Fatty Liver Disease
Memory and Brain Function
Migraine
Schizophrenia
Triglycerides (high)

Products containing niacin (vitamin B3)

Health Concerns

Brands

Evidence supporting the use of: Niacin (vitamin B3)
For the health condition: Cholesterol (high)

Table of Contents

Synopsis

Other ingredients used for Cholesterol (high)

Other health conditions supported by niacin (vitamin B3)

Products containing niacin (vitamin B3)

Health Concerns

Brands

Evidence supporting the use of: Niacin (vitamin B3)For the health condition: Cholesterol (high)

Table of Contents

Synopsis

Other ingredients used for Cholesterol (high)

Other health conditions supported by niacin (vitamin B3)

Products containing niacin (vitamin B3)

Evidence supporting the use of: Niacin (vitamin B3)
For the health condition: Cholesterol (high)