Evidence supporting the use of: Flaxseed
For the health condition: Cholesterol (low)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Flaxseed is scientifically supported for its role in lowering cholesterol levels. Multiple randomized controlled trials and meta-analyses have demonstrated that flaxseed, particularly when consumed as ground flaxseed, can reduce total and LDL ("bad") cholesterol concentrations in both healthy individuals and those with hypercholesterolemia. The cholesterol-lowering effects are attributed primarily to the high content of soluble fiber, lignans, and alpha-linolenic acid (ALA) in flaxseed. Soluble fiber binds bile acids in the digestive tract, leading to increased excretion and reduced cholesterol absorption. Lignans and ALA may also contribute through anti-inflammatory and antioxidant mechanisms.

A 2015 meta-analysis published in the journal Atherosclerosis found that flaxseed supplementation significantly reduced both total cholesterol and LDL cholesterol, particularly in subjects with elevated cholesterol at baseline. Another meta-analysis in 2012 concluded similar findings, especially when flaxseed was provided in doses of at least 30 grams per day. However, the effects on HDL ("good") cholesterol and triglycerides are less consistent across studies.

Clinical guidelines, such as those from the National Lipid Association, recognize the potential benefit of dietary flaxseed as an adjunct to other lipid-lowering strategies. While flaxseed is not a replacement for statins or other pharmacological treatments in individuals with high cardiovascular risk, it is considered a safe and evidence-based dietary option for supporting healthy cholesterol levels.

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