Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Amino acids, particularly branched-chain amino acids (BCAAs) and specific amino acids like L-carnitine, have been investigated for their role in supporting patients with Chronic Obstructive Pulmonary Disease (COPD). Muscle wasting and protein-energy malnutrition are common complications in COPD, often leading to decreased muscle strength, reduced exercise capacity, and poorer clinical outcomes. Several clinical studies suggest that supplementation with amino acids or BCAAs may help counteract muscle loss and improve physical function in COPD patients.

Randomized controlled trials have shown modest improvements in muscle mass, handgrip strength, and exercise tolerance with amino acid supplementation, particularly when combined with exercise training. However, the magnitude of these effects is generally small to moderate, and not all studies have found significant benefits. The underlying rationale is that protein and amino acid supplementation may address the increased protein turnover and anabolic resistance seen in COPD-related muscle wasting.

While there is a scientific basis and some clinical evidence to support the adjunctive use of amino acids for nutritional support in COPD, particularly in malnourished individuals, the overall quality and consistency of the evidence is moderate at best. Amino acids are not a primary therapy for COPD itself but may be considered as part of a comprehensive nutritional and rehabilitation strategy. Large, well-controlled trials are still needed for definitive recommendations.

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