Evidence supporting the use of: Nicotinamide riboside
For the health condition: Chronic Obstructive Pulmonary Disorder

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Nicotinamide riboside (NR) is a form of vitamin B3 and a precursor to nicotinamide adenine dinucleotide (NAD+), an essential molecule involved in cellular energy metabolism and repair processes. In the context of Chronic Obstructive Pulmonary Disorder (COPD), recent scientific interest has grown around the potential role of NR in supporting mitochondrial function and countering the oxidative stress and inflammation that characterize the disease. Preclinical studies in animal models and cell cultures have shown that NAD+ levels are decreased in the lungs of subjects with COPD, and supplementation with NR can restore NAD+ levels, improve mitochondrial function, and potentially reduce lung inflammation and tissue damage. A few small human studies and pilot clinical trials have begun to explore NR supplementation in COPD patients, suggesting that NR can safely increase NAD+ levels in blood and may have modest effects on vascular function and inflammation, but clear benefits on major clinical outcomes (such as lung function or exacerbation rates) have yet to be robustly demonstrated. Currently, the evidence is limited and preliminary. The use of NR in COPD is based on a plausible biological mechanism and encouraging animal data, but there is a lack of large, well-controlled human trials proving efficacy. Thus, the evidence supporting NR for COPD is scientifically inspired but remains weak, meriting a score of 2/5. NR supplementation is not considered a standard or primary therapy for COPD at this time.

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