Arginine aspartate is sometimes used as a supplement to support circulation, primarily due to the properties of L-arginine, an amino acid that serves as a precursor for nitric oxide (NO) synthesis. Nitric oxide acts as a vasodilator, helping relax blood vessels and thus supporting blood flow. Several studies have investigated L-arginine alone for conditions related to poor circulation, such as peripheral arterial disease and intermittent claudication, with modest improvements noted in some trials. However, the evidence is inconsistent, and the clinical benefits are often limited and not universally accepted.

Regarding arginine aspartate specifically, there is less robust data. Some European studies from the late 20th century explored its use for fatigue and circulatory disorders, but these were often small, not rigorously controlled, or not published in high-impact journals. The aspartate component is believed to potentially aid in cellular energy metabolism, but its specific contribution to circulation is not well established.

Overall, while the theoretical basis for arginine aspartate’s use in circulation is linked to L-arginine’s role in nitric oxide production and vasodilation, the direct clinical evidence for arginine aspartate improving poor circulation is weak. Most guidelines do not recommend it as a primary therapy. Thus, the evidence supporting its use for this indication rates as low to moderate.