Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Dodeca-2E,4E,8Z,10Z-tetraenoic acid isobutylamide is a principal alkamide compound found in Echinacea species, especially Echinacea angustifolia and Echinacea purpurea. While Echinacea is best known for its use in supporting immune function, some preclinical studies and limited clinical research suggest that its alkamide constituents, including dodeca-2E,4E,8Z,10Z-tetraenoic acid isobutylamide, may have effects on vascular function and blood flow. This is attributed to the interaction of alkamides with cannabinoid receptors (CB2), which are expressed in vascular tissues and influence vasodilation and inflammation. In vitro studies demonstrate some vasorelaxant activity, and animal research has indicated potential antiplatelet and anti-inflammatory effects, which could theoretically benefit circulation. However, direct clinical evidence supporting the use of this specific compound or Echinacea alkamides for improving circulation or treating poor circulation in humans is minimal and mostly indirect. The scientific rating is therefore moderate to low (2/5), as the majority of evidence comes from mechanistic or animal studies rather than robust human trials. In summary, while there is a plausible scientific rationale and some preliminary data, the use of dodeca-2E,4E,8Z,10Z-tetraenoic acid isobutylamide for poor circulation is not yet strongly validated in clinical settings.

More about dodeca-2E, 4E, 8Z, 10Z/tetraenoic acid isobutylamide
More about Circulation (poor)

Other ingredients used for Circulation (poor)

Acetyl L-carnitine
Ajoene
algal oil
alpha-linolenic acid (ALA)
amino acids
anthocyanins
arjun tree
ashwagandha
asparagus
astaxanthin
astragalus
beet
bergamot
berry flavor
bilberry
black cumin
black currant
black garlic
black pepper
sesame
black tea
blueberry
bromelain
bupleurum falcatum
burdock
butcher's broom
caffeine
capsaicinoids
cat's claw
caterpillar mushroom
celery
chen pi
cherry
Chinese salvia root
chokeberry
cinnamon
citrus bioflavonoids
citrus sinensis (proprietary)
clove
coenzyme Q10 (CoQ10)
Coleus forskohlii
cordyceps
turmeric
curcumin
d-alpha tocopherol
DHA (docosahexaenoic acid)
diallyl disulfide (DADS)
diallyl trisulfide (DATS)
dong quai root
eleuthero
EPA (eicosapentaenoic acid)
fish oil
fish protein
flavonols
flaxseed
fruit and vegetable blend (proprietary)
garlic bulb
ginger
ginkgo biloba
ginseng
gooseberry
gotu kola
grape
onion
green tea
greens blend (proprietary)
hawthorn
hesperetin
hesperidin
hibiscus
horse chestnut
horseradish
Indian tinospora
iron
knotweed
kudzu
L-arginine
l-carnitine
L-citrulline
lovage
mackerel
magnesium
Marine lipid
Moringa
mustard seed
Naringin
Nattokinase
Nettle
Niacin (vitamin B3)
Niacinamide (vitamin B3)
nicotinamide riboside
olive
omega-3 fatty acids
orange
oyster mushroom
pine bark
policosanol
pomegranate
quercetin
redcurrant
reishi mushroom
resveratrol
rhizome
rose hips
rosemary
rutin
safflower oil
sardines
shiitake mushroom
black ginger
spinach
tocotrienols
Triphala
ubiquinol
vegetable and fruit blend (proprietary)
vegetable blend (proprietary)
vitamin B
vitamin E
seaweed
Water
Watercress
Watermelon
Mulberry
sarsaparilla
suma
jiaogulan
tangerine
gastrodia
cardamom
atractylodes
capsicum
Indian bael
inula racemosa
punarnava
commiphora
smilax
blackboard tree
Caesalpinia crista
peony
lingzhi
Szechuan lovage
prickly ash
siler root
cistanche
dioscorea
dodder
ganoderma
Morinda
zanthoxylum
birch
polyphenols
purslane
Yerba mate
biota seed
goji berry
herbal blend (proprietary)
Sichuan pepper
Yohimbe
cocoa
AMP-activated protein kinase (AMPK)
enzymes blend (proprietary)
cayenne pepper
ashitaba
2-(nitrooxy)ethyl 2-amino-3-methylbutanoate
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
Aralia
arjuna
arginine alpha ketoglutarate
antler
Autumn elaeagnus
arginine creatine
Arginine nitrate
Angelica
Aronia melanocarpa
Allicin
Arginine aspartate
Achyranthes
Auricularia
Adrenergic amines
alpha-lipoic acid
astragaloside
anthocyanidins
Asteraceae
arjunic acid
Alliin
anthocyanosides
Allium tuberosum
Arginine silicate
atractylone
bishop\'s weed
Butea monosperma
black galingale
berry
bur-reed
bioflavonoids
bee products
Buddha\'s hand
Buckwheat
Bassia scoparia
Boerhavia diffusa
borneol
coumarin
Centella triterpenes
Chinese silkvine
Cinnamomum
Chinese mountain ant
carqueja
calycosin
capsinoids
Codonopsis
capillary artemisia
cyanidin
Curcuminoid
Citrus
capsaicin
catecholamine
cowherb
curcumen
Centella asiatica
coca
chocolate
Curcuma
chestnut
cinnamaldehyde
costus
Carthamus
cola nut
currant
diallyl sulfide
Diosmin
dismutase
danshen
dong quai
date
diosmetin
dodeca-2E, 4E, 8Z, 10Z/tetraenoic acid isobutylamide
epicatechin
Eupolyphaga sinensis
elk antler
evodiamine
eicosapentaenoic acid
essential oil blend
ephedrine
Ethylenediaminetetraacetic acid (EDTA)
European five-finger grass
Echium
fruit
flavonoids
fo-ti
flat-stem milk-vetch
fatty acids
fungus
flavanones
Fagopyrum
flavoglycosides
flavans
forskolin
flavonones
flavanols
flavones
Ginsenosides
Glycoside
Gypenoside
garlic
Growth factors
ginkgo flavone glycoside
Hygrophila
heal-all
hazelnut
hydroxytyrosol
Herb Robert
Huang hua
inositol nicotinate
Ilex
long pepper
icariin
Indian kinotree
kola nut
lumbrokinase
Ligustrazin
Ligusticum
Monacolin
mandarin
maral root
Mountain Pepper
Mustard
mace
Monounsaturated fat
Mistletoe
Marine fat
Mate
Mushroom
Nutmeg
Oleuropein
Oligomeric proanthocyanidins
Oxystelma
Piperine
Puerarin
Piper chaba
Phenylpropanoids
Phaeophyceae
procyanidol
procyanidin
Pentacyclic triterpenoids
Polydatin
proanthocyanidins
Propionyl-L-Carnitine
polyunsaturated fat
Pepper
Pyrrosia
Phthalides
Piper retrofractum
punicalagins
paeoniflorin
Pycnogenol
Pistachio
Polygonum
Ruscus
rockweed
Ruscogenins
Rutosides
ribose
Rosa roxburghii
Sichuan Lovage
Sete sangrias
Serrapeptase
Southern Tsangshu
Sickle-leaf hare's ear
Salmon Oil
Salidroside
Salvianolic acid
Shogaol
Schisandrins
Spatholobus
saponins
Sumac
Sulfated polysaccharide
Shilajit
S-allylcysteine
Sweet Orange alcohol
Terminalia
Theobromine
Tea
Taxifolin
Troxerutin
Triterpenes
Taxillus chinensis
Tanshinone
Taraxacum
Vinburnine
Vincamine
Withanolides
Wulinshen
Xantinol Nicotinate
Xanthophyll
Xylaria nigripes
Xanthone
Yohimbine
Zucchini
Zingerone

Other health conditions supported by dodeca-2E, 4E, 8Z, 10Z/tetraenoic acid isobutylamide

Circulation (poor)
Colds (general)
Colds (prevention)
Inflammation
Pain (general remedies for)
Sore Throat
Stress

Products containing dodeca-2E, 4E, 8Z, 10Z/tetraenoic acid isobutylamide

We currently have no products on Vitabase that contain this ingredient.