Evidence supporting the use of: Ginkgolide B
For the health condition: Circulation (poor)
Synopsis
Source of validity: Traditional
Rating (out of 5): 2
Ginkgolide B is a terpene lactone found in the leaves of the Ginkgo biloba tree. Its use to support or treat poor circulation is primarily rooted in traditional medicine, particularly within Traditional Chinese Medicine (TCM), where Ginkgo biloba extracts have been used for centuries to promote blood flow and treat circulatory disorders. The rationale behind this traditional use is based on the observed effects of Ginkgo extracts, including improved peripheral blood flow and relief of symptoms such as cold extremities and intermittent claudication.
From a scientific perspective, most clinical studies focus on standardized Ginkgo biloba extracts, which contain ginkgolides (including Ginkgolide B) as well as flavonoids. Some evidence from randomized controlled trials suggests these extracts may provide modest benefits for intermittent claudication and peripheral arterial disease, potentially by improving blood viscosity and promoting vasodilation. However, it is important to note that these effects are attributed to the whole extract rather than to Ginkgolide B in isolation. The specific evidence for Ginkgolide B alone in improving circulation is limited and not well-characterized in clinical studies.
In summary, while the traditional use of Ginkgo biloba (containing Ginkgolide B) for poor circulation is well-documented, direct scientific validation for Ginkgolide B as a monotherapy is lacking. The evidence supporting the use of Ginkgo extracts for circulation is modest (hence the rating of 2), and its application is based more on tradition and studies of the whole extract rather than the isolated compound.
Other ingredients used for Circulation (poor)
acetyl l-carnitineajoene
algal oil
alpha-linolenic acid (ALA)
amino acids
anthocyanins
arjun tree
ashwagandha
asparagus
astaxanthin
astragalus
beet
bergamot
berry flavor
bilberry
black cumin
black currant
black garlic
black pepper
sesame
black tea
blueberry
bromelain
bupleurum falcatum
burdock
butcher's broom
caffeine
capsaicinoids
cat's claw
caterpillar mushroom
celery
chen pi
cherry
Chinese salvia root
chokeberry
cinnamon
citrus bioflavonoids
citrus sinensis (proprietary)
clove
coenzyme Q10 (CoQ10)
coleus forskohlii
cordyceps
turmeric
curcumin
d-alpha tocopherol
DHA (docosahexaeonic acid)
diallyl disulfide (DADS)
diallyl trisulfide (DATS)
dong quai root
eleuthero
EPA (eicosapentaenoic acid)
fish oil
fish protein
flavonols
flaxseed
fruit and vegetable blend (proprietary)
garlic bulb
ginger
ginkgo biloba
ginseng
gooseberry
gotu kola
grape
onion
green tea
greens blend (proprietary)
hawthorn
hesperetin
hesperidin
hibiscus
horse chestnut
horseradish
Indian tinospora
iron
knotweed
kudzu
l-arginine
l-carnitine
l-citrulline
lovage
mackerel
magnesium
marine lipid
moringa
mustard seed
naringin
nattokinase
nettle
niacin (vitamin B3)
niacinamide (vitamin B3)
nicotinamide riboside
olive
omega-3 fatty acids
orange
oyster mushroom
pine bark
policosanol
pomegranate
quercetin
redcurrant
reishi mushroom
resveratrol
rhizome
rose hips
rosemary
rutin
safflower oil
sardines
shiitake mushroom
black ginger
spinach
tocotrienols
triphala
ubiquinol
vegetable and fruit blend (proprietary)
vegetable blend (proprietary)
vitamin B
vitamin E
seaweed
water
watercress
watermelon
mulberry
sarsaparilla
suma
jiaogulan
tangerine
gastrodia
cardamom
atractylodes
capsicum
Indian bael
inula racemosa
punarnava
commiphora
smilax
blackboard tree
caesalpinia crista
peony
lingzhi
lingusticum wallichii
prickly ash
siler root
cistanche
dioscorea
dodder
ganoderma
morinda
zanthoxylum
birch
polyphenols
purslane
yerba mate
biota seed
goji berry
herbal blend (proprietary)
Sichuan pepper
yohimbe
cocoa
AMP-activated protein kinase (AMPK)
enzymes blend (proprietary)
cayenne pepper
ashitaba
2-(nitrooxy)ethyl 2-amino-3-methylbutanoate
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
Aralia
Arjuna
Arginine Alpha Ketoglutarate
Antler
Autumn elaeagnus
Arginine Creatine
Arginine nitrate
Angelica
Aronia melanocarpa
Allicin
Arginine aspartate
Achyranthes
Auricularia
Adrenergic amines
Alpha-Lipoic Acid
Astragaloside
anthocyanidins
Asteracea
Arjunic Acid
Alliin
anthocyanosides
Allium tuberosum
Arginine silicate
Atractylone
Bishop's Weed
Butea monosperma
Black galingale
berry
Bur-Reed
Bioflavonoids
Bee products
Buddha's Hand
Buckwheat
Bassia scoparia
Boerhavia diffusa
Borneol
Coumarin
Centella triterpenes
Chinese Silkvine
Cinnamomum
Chinese Mountain Ant
Carqueja
Calycosin
Capsinoids
Codonopsis
Capillary Artemisia
Cyanidin
Curcuminoid
Citrus
Capsaicin
Catecholamine
Cowherb
Curcumen
Centella asiatica
Coca
Chocolate
Curcuma
Chestnut
Cinnamaldehyde
Costus
Carthamus
cola nut
Currant
Diallyl sulfide
Diosmin
Dismutase
Danshen
Dong Quai
Date
Diosmetin
Dodeca-2E, 4E, 8Z, 10Z/Etetraenoic Acid Isobutylamide
epicatechin
Eupolyphaga sinensis
Elk antler
Eicosapentaenoic Acid
Essential Oil Blend
Ephedrine
Ethylenediaminetetraacetic acid (EDTA)
European-Five Finger Grass
Echium
Flavonoids
Flavonones
Garlic
Mustard
Mistletoe
Pistachio
Sumac
Sweet Orange alcohol
yohimbine
Zucchini
Other health conditions supported by Ginkgolide B
Alzheimer's DiseaseAsthma
Circulation (poor)
Circulation (to the brain)
Dementia
Inflammation
Memory and Brain Function
Migraine