Grape, particularly in the form of grape seed extract (GSE), is supported by scientific evidence for its use in treating poor circulation. The key active components are oligomeric proanthocyanidin complexes (OPCs), which possess strong antioxidant properties. Several clinical studies have investigated the effects of GSE on venous insufficiency and edema, conditions associated with poor circulation, especially in the legs. Research suggests that GSE can improve symptoms such as heaviness, swelling, and discomfort in individuals with chronic venous insufficiency (CVI). A meta-analysis published in the journal Phytotherapy Research (2016) concluded that GSE significantly reduced leg swelling and improved subjective symptoms of CVI compared to placebo.

The proposed mechanisms include strengthening blood vessel walls, reducing oxidative stress, and improving microcirculation. Grape polyphenols may also reduce inflammation, another contributor to circulatory problems. While the majority of studies support the effectiveness of grape seed extract, it is important to note that most research has focused on standardized extracts rather than whole grapes or grape juice, and long-term safety data are still limited.

In summary, grape seed extract is one of the better-studied natural remedies for poor circulation, with moderate-quality evidence supporting its use for mild-to-moderate venous insufficiency. However, it should not be considered a replacement for conventional medical treatment in severe cases.