Evidence supporting the use of: Punicalagins
For the health condition: Circulation (poor)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Punicalagins are polyphenolic compounds predominantly found in pomegranate (Punica granatum) and have attracted scientific interest for their potential cardiovascular and circulatory benefits. Several in vitro and animal studies suggest that punicalagins possess strong antioxidant and anti-inflammatory properties. These effects can reduce oxidative stress and endothelial dysfunction, both of which are linked to poor circulation and the development of cardiovascular diseases.

Human clinical evidence, however, remains limited. Some small-scale trials involving pomegranate juice (which contains punicalagins) have demonstrated improvements in endothelial function, reductions in blood pressure, and enhanced blood flow. These effects are hypothesized to arise from the polyphenols’ ability to increase nitric oxide availability, leading to vasodilation, and to reduce LDL oxidation, a factor in atherosclerosis. However, the specific contribution of isolated punicalagins, compared to other pomegranate constituents, is not fully delineated. Most studies use whole pomegranate extracts or juice, making it difficult to attribute effects solely to punicalagins.

In summary, while there is a scientific rationale and some preliminary evidence supporting the use of punicalagin-containing pomegranate extracts for circulatory health, the direct evidence for isolated punicalagins in humans is limited. The current level of evidence justifies a moderate but not strong rating for the use of punicalagins in supporting poor circulation.

More about punicalagins
More about Circulation (poor)

Other ingredients used for Circulation (poor)

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Products containing punicalagins

We currently have no products on Vitabase that contain this ingredient.