Salidroside, a bioactive compound primarily found in Rhodiola rosea, has a history of use in traditional medicine systems, particularly in Russia, Scandinavia, and China. Traditionally, Rhodiola has been used as an adaptogen to help the body resist physical, chemical, and biological stressors. One of its folk uses has been for enhancing stamina, reducing fatigue, and supporting overall vitality, which sometimes includes claims of improving circulation or cardiovascular health. However, this traditional use is based more on empirical observations and holistic interpretations than on rigorous scientific validation.

Scientific studies directly evaluating salidroside’s effects on poor circulation in humans are limited. Some preclinical (animal and in vitro) research suggests that salidroside may have vasoprotective effects, such as promoting endothelial cell health, reducing oxidative stress, and possibly enhancing nitric oxide production. These effects could theoretically benefit circulation, but such findings remain preliminary and have not been robustly confirmed in human clinical trials specifically targeting circulatory insufficiency. Therefore, while there is traditional use and some suggestive preclinical evidence, scientific validation for using salidroside to treat or support poor circulation is limited, and current evidence does not support strong clinical recommendations.