Evidence supporting the use of: 1,3,7-Trimethylpurine-2,6-dione
For the health condition: Circulation (to the brain)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

1,3,7-Trimethylpurine-2,6-dione is the chemical name for caffeine. Caffeine is widely used and studied for its effects on the central nervous system, including cerebral (brain) circulation. Scientific research indicates that caffeine acts as an adenosine receptor antagonist, which leads to vasoconstriction of cerebral blood vessels. While this vasoconstriction might seem to reduce blood flow, caffeine’s stimulatory effects can result in increased alertness and improved cognitive function, which some interpret as “supporting” brain circulation. Some studies have shown that caffeine can increase cerebral perfusion pressure and may benefit certain aspects of cognitive performance, though these effects are usually acute and not necessarily indicative of long-term improvement in brain circulation. There is also evidence that caffeine can alleviate headache symptoms by constricting dilated blood vessels in the brain.

However, chronic use of caffeine can lead to tolerance, and its net effects on cerebral blood flow may change over time. The scientific evidence supporting caffeine’s use to directly “support” or “treat” brain circulation is moderate, with most benefits related to cognitive enhancement and alertness rather than direct improvement in cerebral blood supply. Therefore, while there is scientific evidence for caffeine’s acute effects on the brain and its circulation, the overall support for its use specifically for brain circulation is limited and should be considered with caution.

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