Flavonoids are a diverse group of plant-derived polyphenolic compounds commonly found in fruits, vegetables, tea, and wine. Their use to support circulation, including cerebral (brain) circulation, is primarily based on their antioxidant, anti-inflammatory, and vasodilatory properties. Several scientific studies, both in vitro and in vivo, suggest that flavonoids can improve endothelial function, enhance nitric oxide production, and protect blood vessels from oxidative stress, all of which may contribute to better blood flow to the brain.

Clinical studies have specifically examined certain flavonoid-rich extracts, such as Ginkgo biloba (standardized to contain flavone glycosides) and citrus flavonoids, for their effects on cerebrovascular circulation. Some research has shown modest improvements in cognitive function and blood flow in patients with mild cognitive impairment or age-related cognitive decline, although results are mixed and often limited by study quality and size. Systematic reviews and meta-analyses suggest a potential benefit, but emphasize the need for more rigorous, large-scale trials to firmly establish efficacy.

While the evidence does not unequivocally confirm flavonoids as a treatment for poor cerebral circulation, the biological plausibility and some positive clinical findings justify their consideration as supportive agents. Therefore, flavonoid mixtures are used with some scientific backing, though more research is needed to clarify the extent of their benefit.