Evidence supporting the use of: Ginkgolide A
For the health condition: Circulation (to the brain)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Ginkgolide A and Cerebral Circulation: Scientific Synopsis

Ginkgolide A is one of the major terpene lactones found in Ginkgo biloba extracts. Ginkgo biloba has a long tradition of use in supporting cognitive function and cerebral blood flow, especially in Traditional Chinese Medicine, but the specific role of ginkgolide A is a subject of scientific investigation.

Preclinical studies show that ginkgolide A acts as a platelet-activating factor (PAF) antagonist, which can reduce platelet aggregation and potentially enhance microcirculation. Some animal and in vitro studies suggest this may help protect against ischemic damage and improve blood flow in the brain.

Clinical studies on Ginkgo biloba extract (which contains ginkgolide A among other compounds) have reported modest improvements in symptoms related to cognitive impairment and vascular dementia, and some trials report improved cerebral blood flow. However, very few studies isolate the effects of ginkgolide A alone; most data come from standardized extracts such as EGb 761, which contain a mix of active ingredients.

Overall, there is moderate scientific evidence (rating 3/5) supporting the use of Ginkgo biloba extracts for cerebral circulation, but the specific contribution of ginkgolide A requires further research. Its use is justified by a combination of tradition and emerging scientific data, but direct clinical validation for ginkgolide A alone is still limited.

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