Evidence supporting the use of: Vincamine
For the health condition: Circulation (to the brain)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vincamine is an alkaloid derived from the plant Vinca minor (lesser periwinkle). It has been studied primarily for its potential effects on cerebral circulation and cognitive function. The use of vincamine as a cerebral vasodilator stems from research conducted in the mid-to-late 20th century, particularly in Europe. Pharmacological studies have shown that vincamine can increase cerebral blood flow by dilating blood vessels in the brain, thereby potentially improving oxygen and nutrient delivery to neural tissues. This mechanism has led to its use in some countries as a treatment for conditions associated with cerebrovascular insufficiency, such as age-related cognitive decline, dizziness, and memory disturbances.

However, the quality of clinical evidence supporting vincamine’s efficacy is limited. Most studies are small, lack rigorous methodology, or have not been replicated in large-scale, placebo-controlled trials. Systematic reviews have generally found insufficient evidence to conclusively recommend vincamine for cognitive impairment or stroke prevention. It is approved for clinical use in some European countries, but its use is not widespread or recommended by major international guidelines. Side effects, particularly at higher doses, can include hypotension and cardiac disturbances.

In summary, while there is some scientific rationale and modest clinical evidence for vincamine’s use in supporting cerebral circulation, the overall quality and strength of evidence are limited, justifying a moderate evidence rating.

More about Vincamine
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Products containing Vincamine

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