Evidence supporting the use of: Cynarin
For the health condition: Cirrhosis of the Liver

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Cynarin is a compound primarily found in artichoke (Cynara scolymus) and has been traditionally used in herbal medicine, particularly in Europe, for supporting liver health, including in cases of liver dysfunction such as cirrhosis. Historical use of artichoke extracts for liver and gallbladder complaints dates back to the 16th century. The traditional rationale is based on artichoke’s perceived ability to promote bile flow (choleretic effect) and support general liver detoxification processes. Some early herbal texts and ethnobotanical sources mention the use of artichoke preparations for “liver weakness” and related symptoms.

However, scientific evidence specifically supporting cynarin or artichoke extract in the treatment or support of cirrhosis of the liver is limited. While several animal and in vitro studies suggest that artichoke extract may have antioxidant, hepatoprotective, and choleretic properties, high-quality clinical trials in humans with cirrhosis are lacking. Most available studies focus on general liver support or protection against chemically-induced liver injury rather than established cirrhosis. Some small human studies suggest potential benefits in liver enzyme normalization, but these studies often involve mild liver dysfunction or nonalcoholic fatty liver disease, not cirrhosis per se.

In summary, the use of cynarin for cirrhosis is primarily supported by traditional herbal medicine practices rather than robust scientific validation, and the overall evidence rating for its effectiveness in this specific condition is low.

More about cynarin
More about Cirrhosis of the Liver

Products containing cynarin

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