Evidence supporting the use of: Ferulic acid derivative
For the health condition: Cirrhosis of the Liver

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Ferulic acid derivatives, particularly sodium ferulate, have been used in some Asian countries, especially China, as adjunct therapies for liver diseases, including cirrhosis. The rationale for their use is primarily based on their antioxidant, anti-inflammatory, and anti-fibrotic properties observed in preclinical studies. Laboratory experiments and some animal models have demonstrated that ferulic acid can reduce liver fibrosis by inhibiting the activation of hepatic stellate cells and decreasing oxidative stress, both of which are key processes in the progression of cirrhosis. Small clinical trials and observational studies in humans, mainly from Chinese literature, suggest that sodium ferulate may improve liver function tests and symptoms in patients with cirrhosis, but these studies often have methodological limitations such as small sample sizes, lack of blinding, or insufficient controls.

There is not yet robust, large-scale, placebo-controlled clinical trial evidence to fully validate the effectiveness of ferulic acid derivatives in treating cirrhosis. Most Western clinical guidelines do not mention or recommend ferulic acid derivatives for this indication. Therefore, while there is some scientific evidence—mainly preliminary and from non-Western sources—for potential benefit, the overall quality of evidence remains low (rated 2/5). Further rigorous research is required to determine their true efficacy and safety in patients with cirrhosis.

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