Evidence supporting the use of: Fucoidan
For the health condition: Cirrhosis of the Liver

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Fucoidan is a sulfated polysaccharide found in brown seaweeds and has been investigated for various biological activities, including anti-inflammatory, antioxidant, and antifibrotic effects. In the context of liver cirrhosis, some preclinical studies (primarily in animal models) suggest that fucoidan may help reduce liver fibrosis by modulating inflammatory and fibrogenic pathways. For example, research published in journals such as Marine Drugs and Liver International has shown that fucoidan can attenuate liver injury and suppress the activation of hepatic stellate cells, which are central to the development of fibrosis. Additionally, fucoidan’s antioxidant properties may help mitigate oxidative stress, a known contributor to liver damage.

However, clinical evidence in humans is very limited. A few small pilot trials and case reports have explored its safety and potential benefits, but robust, large-scale randomized controlled trials are lacking. As a result, while the scientific rationale and preclinical data are promising, the overall evidence supporting fucoidan’s use for cirrhosis of the liver remains preliminary. Its use is not supported by established treatment guidelines, and it should not replace conventional therapies. Instead, it may be considered as an adjunct under medical supervision, pending further research.

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Products containing fucoidan

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