Evidence supporting the use of: Oleanolic acid
For the health condition: Cirrhosis of the Liver

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Oleanolic acid is a naturally occurring triterpenoid compound found in many plants, including olives and various medicinal herbs. Its use in the context of liver disorders, including cirrhosis, primarily stems from preclinical and some early clinical research rather than traditional medicine. Scientific studies, especially in China, have explored oleanolic acid's hepatoprotective (liver-protecting) properties. Experimental models have shown that oleanolic acid possesses anti-inflammatory, antioxidant, and anti-fibrotic effects, which are relevant to the pathophysiology of cirrhosis—a condition characterized by progressive liver fibrosis and impaired hepatic function. In animal studies, oleanolic acid has demonstrated the ability to reduce liver injury induced by toxins and to inhibit fibrosis by modulating inflammatory pathways and reducing oxidative stress. Some small-scale clinical studies and reviews suggest potential benefits in chronic liver diseases, but robust, large-scale, placebo-controlled clinical trials in humans with cirrhosis are lacking. In China, oleanolic acid and its derivatives are included in some formulations approved for supportive treatment of liver diseases, reflecting a translational step from experimental to clinical use. Nevertheless, the overall quality and quantity of human evidence for oleanolic acid in the management of cirrhosis are limited. While the scientific rationale is promising and preclinical evidence is encouraging, its efficacy and safety for human cirrhosis patients are not yet well-established. Therefore, the evidence rating is moderate (2/5), and its use should be considered experimental and adjunctive rather than standard therapy.

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