Evidence supporting the use of: Phospholipids (unspecified)
For the health condition: Cirrhosis of the Liver

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Phospholipids, particularly in the form of "essential phospholipids" (EPL), have been studied for their potential role in the management of liver diseases, including cirrhosis. The rationale for their use is based on the idea that phospholipids are key components of cellular membranes, and supplementation may help restore membrane integrity in damaged liver cells. Several clinical trials, primarily conducted in Eastern Europe and Asia, have investigated the use of EPLs (often derived from soybeans) in patients with chronic liver diseases, including cirrhosis. Some studies have reported improvements in biochemical markers of liver function (such as ALT, AST, and bilirubin levels), as well as histological findings and symptoms. However, many of these studies have significant methodological limitations, including small sample sizes, lack of blinding, and inconsistent outcome measures.

Systematic reviews and meta-analyses have concluded that while there is some evidence suggesting a potential benefit of phospholipids in liver disease, the overall quality of evidence is low and findings are inconsistent. Major liver disease guidelines, including those from the American Association for the Study of Liver Diseases (AASLD) and the European Association for the Study of the Liver (EASL), do not recommend phospholipids as standard therapy for cirrhosis due to insufficient high-quality evidence. In summary, while there is some scientific investigation and modest tradition of use, robust clinical validation is lacking, and phospholipids are not universally endorsed for the treatment of cirrhosis.

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