Evidence supporting the use of: Phyllanthus urinaria
For the health condition: Cirrhosis of the Liver

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Phyllanthus urinaria, commonly known as chamber bitter, has a long history of use in traditional medicine systems, particularly in Asia, for various liver ailments including cirrhosis. Its use is primarily rooted in ethnomedicinal practices, where it is believed to support liver health, reduce inflammation, and promote detoxification. The traditional basis comes from its inclusion in herbal remedies for jaundice, hepatitis, and liver dysfunction in Ayurvedic, Chinese, and Southeast Asian folk medicine.

Scientific data supporting its efficacy specifically for cirrhosis is limited. Some preclinical studies (in vitro and animal models) suggest that Phyllanthus urinaria possesses hepatoprotective properties, likely due to its antioxidant, anti-inflammatory, and antifibrotic effects. These studies indicate that extracts of the plant may help reduce liver damage and fibrosis markers, but such evidence is preliminary. There are very few human clinical trials, and those that exist generally focus on viral hepatitis rather than cirrhosis specifically. Systematic reviews highlight the lack of robust, high-quality human data.

In summary, while Phyllanthus urinaria is traditionally used for liver conditions and some early-stage preclinical research is promising, there is insufficient scientific validation for its use in treating or supporting cirrhosis of the liver. Its use remains primarily traditional, with a low to moderate evidence rating.

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