Evidence supporting the use of: Reishi mushroom
For the health condition: Cirrhosis of the Liver

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Reishi mushroom (Ganoderma lucidum) has a long history of use in traditional Chinese medicine, where it is prized as a general tonic and "liver-protective" remedy. Its traditional use for liver health, including cirrhosis, is based on historical texts and anecdotal reports rather than large-scale clinical trials. In traditional practice, reishi is believed to "nourish the liver," detoxify the body, and support immune function, all of which are considered important in managing chronic liver diseases like cirrhosis.

Modern scientific studies provide some preclinical evidence that reishi may have hepatoprotective (liver-protecting) effects. Animal studies and in vitro experiments suggest that compounds in reishi, such as triterpenoids and polysaccharides, may reduce liver inflammation, inhibit fibrosis, and scavenge free radicals. However, robust clinical evidence in humans with cirrhosis is lacking. A few small human studies have shown modest improvements in liver enzyme levels with reishi supplementation, but these studies often have methodological limitations, small sample sizes, and short durations.

Overall, while traditional use persists and early laboratory research is promising, there is insufficient high-quality clinical evidence to recommend reishi mushroom as a primary or adjunctive therapy for cirrhosis. Individuals with liver disease should consult healthcare professionals before using reishi, as it may interact with medications or have contraindications in advanced liver disease.

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