Evidence supporting the use of: Schizandrol A
For the health condition: Cirrhosis of the Liver

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Schizandrol A is a bioactive compound found in Schisandra chinensis, a medicinal plant long used in traditional Chinese medicine (TCM). Schisandra and its extracts, including Schizandrol A, have historically been employed to support liver health and treat conditions such as hepatitis and cirrhosis. The traditional rationale centers on Schisandra's reputed hepatoprotective properties and its use as a “liver tonic” in TCM. However, while some preclinical studies (in vitro and animal models) suggest that Schizandrol A and related lignans may offer antioxidant, anti-inflammatory, and hepatoprotective effects—such as reducing liver enzyme levels, preventing lipid peroxidation, and improving liver histology—robust clinical trials in humans with cirrhosis are lacking. Thus, the use of Schizandrol A for cirrhosis is primarily justified by traditional use rather than high-quality scientific validation. Most available scientific evidence is preliminary and indirect, often focusing on liver injury models rather than established cirrhosis. Systematic reviews and major clinical guidelines do not endorse Schizandrol A as a treatment for cirrhosis. Therefore, while there is a foundation in traditional medicine and some supportive preclinical research, the overall evidence remains limited, and more rigorous human studies are necessary to establish efficacy and safety for this condition.

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