Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Selenium is an essential trace element that plays a significant role in antioxidant defense systems, primarily through its incorporation into selenoproteins such as glutathione peroxidase. In the context of cirrhosis of the liver, several studies have observed that patients often have lower selenium levels compared to healthy controls. The rationale for supplementation stems from the role of oxidative stress in liver injury and progression to cirrhosis, with selenium’s antioxidant properties theoretically offering a protective benefit.

A number of small clinical studies and observational reports have shown that selenium supplementation can improve markers of oxidative stress and, in some cases, liver function tests in patients with liver disease, including cirrhosis. However, large-scale randomized controlled trials are lacking, and the evidence for a significant clinical benefit—such as improved survival or reversal of cirrhosis—is weak. Most guidelines do not recommend selenium supplementation as a standard therapy for cirrhosis, except in cases of proven deficiency.

Overall, the use of selenium in cirrhosis is supported by biological plausibility and limited clinical evidence, but strong scientific validation is lacking. The current evidence supports a cautious approach: supplementation may be considered in documented selenium deficiency but is not universally recommended for all patients with cirrhosis.

More about selenium
More about Cirrhosis of the Liver

Other ingredients used for Cirrhosis of the Liver

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