Evidence supporting the use of: Theabrownin
For the health condition: Cirrhosis of the Liver

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Theabrownin is a polyphenolic pigment found in dark (fermented) tea, especially Pu-erh tea. There is some emerging scientific interest in the hepatoprotective (liver-protecting) effects of theabrownin, including in models of liver fibrosis and cirrhosis. Preclinical animal studies have shown that theabrownin can reduce liver damage, suppress inflammatory markers, and decrease hepatic stellate cell activation, which are all relevant to the development of cirrhosis. For example, some rodent studies have demonstrated that theabrownin administration can attenuate carbon tetrachloride (CCl4)-induced liver fibrosis and reduce collagen deposition in the liver, potentially through antioxidant and anti-inflammatory mechanisms. However, the quality and quantity of the available evidence is still limited. Most studies have been conducted in animal models, with very few (if any) robust clinical trials in humans. There is also a lack of long-term safety data and information on optimal dosing. While traditional tea consumption is associated with various health benefits, the specific use of theabrownin as a therapeutic agent for cirrhosis is not established in traditional medicine, and its use is not yet endorsed by clinical guidelines. In summary, there is preliminary scientific evidence from animal studies that supports the potential of theabrownin in protecting against liver fibrosis and cirrhosis, but clinical validation in humans is currently lacking. Thus, the evidence rating for this use is relatively low.

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Products containing Theabrownin

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