Evidence supporting the use of: Thiamine (Vitamin B1)
For the health condition: Cirrhosis of the Liver

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Thiamine (Vitamin B1) is used in the management of patients with cirrhosis of the liver primarily due to the high prevalence of thiamine deficiency in this population, rather than as a direct treatment for cirrhosis itself. Chronic liver disease, especially when associated with alcoholism, often leads to malnutrition and impaired absorption or storage of several vitamins, including thiamine. Thiamine deficiency in these patients can result in severe neurological complications such as Wernicke’s encephalopathy, which is a medical emergency. Several clinical guidelines recommend routine supplementation of thiamine in patients with chronic liver disease and/or those with a history of alcohol abuse to prevent such complications. However, there is limited evidence that thiamine supplementation directly improves liver function or reverses cirrhosis. Instead, its use is focused on correcting or preventing deficiency states that are common in this group. Thus, while there is scientific validation for thiamine supplementation to prevent deficiency-related complications in cirrhosis, the evidence supporting its use for treating or reversing cirrhosis itself is weak (hence, a rating of 2). Key sources include clinical guidelines for the management of alcohol-related liver disease and reviews on the nutritional management of cirrhosis, which emphasize the prevention of thiamine deficiency rather than a direct therapeutic effect on liver tissue.

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Products containing Thiamine (Vitamin B1)

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