Evidence supporting the use of: Vitamin B1 (Thiamine)
For the health condition: Cirrhosis of the Liver

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin B1 (Thiamine) is scientifically used to support patients with cirrhosis of the liver, primarily because individuals with chronic liver disease, especially those with alcoholic cirrhosis, are at increased risk for thiamine deficiency. Cirrhosis is often associated with malnutrition and impaired absorption of nutrients, including thiamine, due to factors such as poor dietary intake, reduced intestinal absorption, and increased urinary losses. Thiamine deficiency can lead to severe neurological complications, most notably Wernicke encephalopathy, a potentially fatal and reversible condition if promptly treated with thiamine supplementation.

Clinical guidelines recommend screening for and treating thiamine deficiency in patients with advanced liver disease, particularly those with a history of alcohol misuse. Several studies and reviews (such as in Hepatology and World Journal of Gastroenterology) note that prophylactic thiamine supplementation is beneficial for patients at risk, helping prevent neurologic complications. However, thiamine supplementation does not directly treat cirrhosis itself or reverse liver damage; rather, it addresses a common and serious complication associated with the condition. The evidence supporting the prevention and treatment of thiamine deficiency in cirrhotic patients is strong, but the evidence for thiamine supplementation improving liver function or halting cirrhosis progression is limited. Thus, its use is scientifically justified to prevent deficiency-related complications, though not as a primary therapy for cirrhosis itself.

More about Vitamin B1 (Thiamine)
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