Evidence supporting the use of: Inositol nicotinate
For the health condition: Cold Hands and Feet

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Inositol nicotinate (also known as hexanicotinate or inositol hexaniacinate) is a form of niacin (vitamin B3) used in some countries as a vasodilator, particularly to address issues related to poor peripheral circulation, such as cold hands and feet (sometimes related to conditions like Raynaud’s phenomenon). The rationale behind its use is that it can help dilate blood vessels and improve blood flow to the extremities, theoretically reducing symptoms of coldness or numbness.

There is some scientific evidence supporting its efficacy for this purpose, but the quality and quantity of evidence are limited. A handful of small clinical studies from the 1980s and 1990s reported modest improvements in symptoms of Raynaud’s phenomenon and other peripheral circulatory problems when patients were given inositol nicotinate. For example, studies published in journals such as Angiology and British Journal of Clinical Practice suggested slight to moderate benefit over placebo. However, these studies often suffered from methodological weaknesses, small sample sizes, and short durations. More recent and larger trials are lacking, and inositol nicotinate is not widely recommended in major clinical guidelines for peripheral vascular disorders.

In summary, while there is some scientific rationale and limited clinical evidence supporting the use of inositol nicotinate for cold hands and feet, the overall level of evidence is low, and its use is not considered standard or strongly validated.

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