Evidence supporting the use of: Cream
For the health condition: Cold Sores

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Creams, particularly those containing antiviral agents such as acyclovir or penciclovir, are scientifically validated for the treatment of cold sores (herpes labialis). The herpes simplex virus (HSV-1) is responsible for causing cold sores, and topical antiviral creams have been shown in multiple randomized controlled trials to reduce the duration of symptoms, speed up healing, and decrease viral shedding if applied at the first sign of an outbreak. These creams do not cure the infection but can significantly reduce discomfort and complications associated with cold sores. The U.S. Food and Drug Administration (FDA) has approved topical acyclovir and penciclovir creams for this indication. Studies have demonstrated that these creams are most effective when used early, ideally during the prodromal phase before blisters appear. Over-the-counter docosanol cream is also supported by clinical evidence as a treatment that can reduce healing time for cold sores. Other creams, such as those containing natural extracts or anesthetics (e.g., lidocaine), may provide symptomatic relief but do not address the underlying viral cause. Overall, the use of antiviral creams for cold sores is backed by robust scientific evidence, with systematic reviews and meta-analyses supporting their efficacy and safety.

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Products containing Cream

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