Evidence supporting the use of: Flavonoids
For the health condition: Cold Sores

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Flavonoids, a diverse group of phytonutrients found in many fruits, vegetables, and plant-based foods, have been investigated for their antiviral and anti-inflammatory properties. Scientific studies indicate that certain flavonoids—such as quercetin, apigenin, and catechins—can inhibit the replication of herpes simplex virus (HSV), the causative agent of cold sores. For example, in vitro studies have demonstrated that these compounds can interfere with various stages of the HSV life cycle, including viral entry and replication. Some animal studies also report reduced severity and frequency of cold sores with flavonoid supplementation.

However, while the laboratory and animal data are promising, there is a lack of robust clinical trials in humans directly confirming the effectiveness of flavonoids for treating or preventing cold sores. Most evidence is preclinical, and there is little direct guidance on dosage or specific flavonoid compounds for this use in humans. The use of flavonoids for cold sores is therefore based on emerging scientific evidence rather than longstanding traditional use. More rigorous, large-scale human studies are needed to establish their efficacy, optimal dosing, and safety profile for this specific application.

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