Evidence supporting the use of: Glycyrrhiza (unspecified)
For the health condition: Cold Sores

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Glycyrrhiza, commonly known as licorice root, has some scientific evidence supporting its use for cold sores (herpes labialis). The key active compound in licorice root, glycyrrhizin, possesses antiviral properties that have been demonstrated in laboratory and limited clinical studies. In vitro research has shown that glycyrrhizin can inhibit the replication of herpes simplex virus (HSV-1), which causes cold sores. Some small-scale clinical trials and case reports suggest that topical preparations containing licorice extract may reduce the severity and duration of cold sore outbreaks. Additionally, glycyrrhizin may exert anti-inflammatory effects, which could provide symptomatic relief.

However, the evidence base is limited: most studies are either preclinical or lack robust, large-scale, randomized controlled trials in humans. There is some traditional use of licorice for various skin conditions, including sores, but the main rationale for its use in cold sores is based on these initial scientific findings rather than established folk medicine. Safety concerns, particularly with long-term or high-dose use of glycyrrhizin (such as potential effects on blood pressure and potassium levels), must also be considered. Overall, while Glycyrrhiza shows promise as a supportive treatment for cold sores, current evidence is modest and more rigorous studies are needed to establish efficacy and safety.

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