Evidence supporting the use of: Glycyrrhizic acid
For the health condition: Cold Sores

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Glycyrrhizic acid, a compound found in licorice root (Glycyrrhiza glabra), has been studied for its antiviral properties, including potential effects against herpes simplex virus (HSV), the causative agent of cold sores. In vitro studies have demonstrated that glycyrrhizic acid can inhibit the replication of HSV-1 and HSV-2 by interfering with viral gene expression and replication processes. Some research also suggests anti-inflammatory effects, which may help reduce the discomfort and healing time associated with cold sores.

However, while laboratory and some animal studies provide a mechanistic basis for glycyrrhizic acid’s antiviral action, clinical evidence in humans is limited. Few small clinical trials or case studies have evaluated topical or oral glycyrrhizic acid for cold sores, with some suggesting modest benefit in reducing symptom duration or severity. Notably, these studies tend to have small sample sizes and methodological limitations, which makes it difficult to draw firm conclusions about efficacy.

Overall, the use of glycyrrhizic acid for cold sores is supported by preliminary scientific findings, but not robust clinical evidence. Thus, it receives a moderate-low evidence rating. More rigorous randomized controlled trials are needed to firmly establish its effectiveness and safety for this indication.

More about glycyrrhizic acid
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Products containing glycyrrhizic acid

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