Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Dodeca-2E,4E,8Z,10Z-tetraenoic acid isobutylamide is a type of alkamide found in the roots of Echinacea species, particularly Echinacea angustifolia and Echinacea purpurea. The traditional use of Echinacea for the prevention and treatment of colds dates back to Native American medicine, where the plant was used for various infections and as a general immune system stimulant. The use of Echinacea extracts, which contain alkamides like dodeca-2E,4E,8Z,10Z-tetraenoic acid isobutylamide, became popular in Western herbal medicine in the late 19th and early 20th centuries, especially for upper respiratory tract infections such as the common cold.

While the specific compound in question is one of the active constituents believed to contribute to Echinacea’s immune-modulating effects, the evidence for efficacy is based on studies evaluating whole plant or extract preparations, not the isolated alkamide. Clinical trials and meta-analyses provide mixed results, with some suggesting a modest reduction in cold incidence or duration and others showing no significant effect. The mechanism is thought to involve modulation of cytokine production and enhancement of phagocytosis, but direct evidence for the specific alkamide’s isolated action is limited. Therefore, the tradition of using Echinacea (and its alkamides) for colds is well established, but robust scientific validation for this constituent alone is lacking, and overall evidence quality is moderate at best.

More about Dodeca-2E, 4E, 8Z, 10Z/Etetraenoic Acid Isobutylamide
More about Colds (general)

Other ingredients used for Colds (general)

Allspice
Aloe vera
green chiretta
anthocyanins
apple
arabinogalactan
astragalus
waterhyssop
bamboo
barberry
basil
benegut perilla (proprietary)
berry flavor
beta-pinene
black cumin
black currant
black garlic
black pepper
radish
black tea
blackberry
blueberry
bupleurum falcatum
burdock
bасора
capsaicinoids
carrot
cassia bark
caterpillar mushroom
chamomile
cinnamon
citrus oil
citrus sinensis (proprietary)
clove
coconut milk
colostrum
turmeric
dog rose
echinacea purpurea
elderberry
forsythia
garlic bulb
ginger
ginseng
gooseberry
grape
greek mountain tea
onion
green tea
greens blend (proprietary)
horseradish
Indian tinospora
honeysuckle
jujube
L-cysteine
lactobacillus fermentum
lactiplantibacillus plantarum
lactobacillus reuteri
lemon
licorice root
lovage
lychee
marshmallow
mastic gum
milk
moringa
mustard seed
nettle
spruce
orange
oregano
oregon grape
pear
perilla
phellodendron amurense
phenolic compounds
pineapple
plantain
plum fruit
pomegranate
pumpkin
quail egg
quercetin
raspberry
redcurrant
reishi mushroom
rhizome
rose hips
rosemary
sage
schizonepeta
scrophularia root
spearmint leaf
sphaeranthus indicus
spirulina
thyme
vegetable blend (proprietary)
vitamin B
vitamin C
vitamin D
Wasabi
water
yeast
zinc
sarsaparilla
squawvine
boneset
tangerine
typhonium
xanthium (cockleburs)
hyssop
cardamom
atractylodes
papaya
capsicum
mugwort
Indian bael
neem tree
nut grass
alpinia galangal
ferula assafoetida
pistacia integerrima gall
commiphora
tinospora cordifolia
blackboard tree
bee pollen
peony
Szechuan lovage
boxthorne
buckthorn
lemongrass
yerba santa
chrysanthemum
siler root
flowering quince
dodder
sweet flag
hyacinth bean
morinda
trichosanthes
zanthoxylum
birch
dulse leaf
purslane
fulvic acid
eucalyptus
menthol oil
aster root
peach
paw paw
Abies spectabilis
horehound
Sichuan pepper
Algae
indigo leaves
cayenne pepper
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
Alcohol
Ash
Aralia
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Apple Cider Vinegar
Agastache
Alpha-terpineol
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Angelica
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Allicin
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Asarum heterotropoides
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Andrographolide
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American Liverleaf
Asam gelugor
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Asteracea
Allyl Sulfide
Allyl isothiocyanate
Alliin
Allium tuberosum
Amor seco
Arani
Atractylone
Bee Propolis
Black Seed
Bermuda Grass
Baikal Skullcap
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berry
Baccharoides anthelmintica
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Bioflavonoids
black salt
Bee products
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Borassus aethiopum
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Bassia scoparia
Belamcanda
Boerhavia diffusa
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Cumin
Camellia sinensis
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Chinese Silkvine
Curry leaf
Cinnamomum
Chinese Mountain Ant
Clerodendrum trichotomum
Cloudberry
coconut oil
Coriander
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Capillary Artemisia
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Curcuminoid
Citrus
Cineole
Capsaicin
Cajuput
Chinese Raisintree
Chlorophytum
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Curcumen
Cistus
Common madia
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Calamus
Coin-leaf desmodium
Cinnamaldehyde
Costus
Carthamus
cola nut
Celosia
Culvers Root
Currant
Chrysophanics
Chondrus
Dianthus
Dodeca-2E, 4E-Dienoic Acid Isobutylamide
Dragonhead
Deoxyandrographolides
David's Milkberry
Desmodium
Dodeca-2E, 4E, 8Z, 10Z/Etetraenoic Acid Isobutylamide
Ephedra
European Elder
Eupolyphaga sinensis
Evodia
English Horsemint
Eclipta
Echinacea
Elder
Essential Oil Blend
European-Five Finger Grass
Embelia
Fruit
Fang-Feng
Flat-stem milk-vetch
Fat liver oil
Ficus simplicissima
Frankincense
Flavonones
Goldthread
Gnaphalium
gamma-terpinene
Garlic
Gallesia
Giant Blazingstar
Glechoma hederacea
Gardenia jasminoides
Gigartina
Glycyrrhizin
Hygrophila
Honey
Heal-All
Hedyotis
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Helicteres isora
Herb Robert
Hemp
Horsemint
iridoids
Iridoid glycosides
Isatis
Ilex
Long Pepper
Indian Fagonia
Joe-Pye
Jungli-bean
Kokilaksha
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Loquat
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Lebbek
Ledebouriella
Litsea
Lomatium
Lichen
Laggera pterodonta
Limonene
Luffa
Ligustrum
Lodhtree
Lotus
Lysozyme
Labrador Tea
Little ironweed
Liverwort
Ligusticum
Linalool
Mandarin
Mountain Pepper
Mustard
Mineral ascorbate
Myrcene
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Marsh Tea
Mallow
Melia
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Monardella odoratissima
Momordica
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Meadowsweet
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Maytenus ilicifolia
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Natsudaidai
Nymphaea nouchali
Nimbidin
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Oroxylum indicum
Osha
Orris
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Osmanthus
Oxystelma
Oryza Sativa
Propolis
Phellodendron
Phyllanthus
Piper chaba
Phenylpropanoids
Phaeophyceae
Pagoda Tree
Pluchea
Potato
Prunus
Phosphate ascorbate
Pepper
Paris polyphylla
Peucedanum
Pelargonium
Pyrrosia
Piper retrofractum
portulaca
Piper nigrum
Polygonatum
Persimmon
Patrinia
Physalis angulata
Polygonum
Petiveria
Quillaja
Rubus
Rubiaceae
Rose
Rooibos
Ravinsara
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Sicklepod
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Sesbania
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Sesquiterpenes
Shark Liver Oil
Sweet Annie
Spikenard
Salvia
Southern Tsangshu
Solanum indicum
Sickle-leaf hare's ear
Sambucus nigra
Sagebrush
Sinigrin
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Sandalwood
Squash
Scabrous Gentian
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Sweet Bay
Sargassum
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Terminalia
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Thymus
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Thaumatococcus daniellii
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Visnea Mocanera
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White Tea
Wax Gourd
Water Pepper
Wulinshen
Winter Begonia
Winter Savory
Yuzu
Yerba buena
Yellow-Fruit Nightshade
Zucchini
Zingiberene
Zingerone

Other health conditions supported by Dodeca-2E, 4E, 8Z, 10Z/Etetraenoic Acid Isobutylamide

Circulation (poor)
Colds (general)
Colds (prevention)
Inflammation
Pain (general remedies for)
Sore Throat
Stress

Products containing Dodeca-2E, 4E, 8Z, 10Z/Etetraenoic Acid Isobutylamide

We currently have no products on Vitabase that contain this ingredient.