Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Yeast, particularly strains like Saccharomyces cerevisiae and baker's yeast derivatives (such as beta-glucans extracted from the cell walls), has been studied for its potential immune-modulating properties. The interest in yeast for cold prevention is driven by research on beta-glucans, complex polysaccharides that may enhance innate immune responses. Several randomized controlled trials and reviews have investigated the effect of yeast-derived beta-glucans on upper respiratory tract infections (URTIs), including the common cold. Some studies, such as those published in peer-reviewed journals like European Journal of Nutrition and Journal of the American College of Nutrition, report a modest reduction in the incidence or duration of colds in individuals supplementing with yeast beta-glucans, especially in people under physical stress (e.g., athletes). However, the overall evidence is mixed and not robust enough to warrant a strong recommendation. Meta-analyses and systematic reviews note variability in study design, dosage, and population, making it difficult to draw definitive conclusions. While the biological plausibility exists—since beta-glucans may prime immune cells such as macrophages and natural killer cells—the clinical significance remains uncertain. In summary, there is some scientific validation for the use of yeast (specifically its beta-glucan components) in supporting cold prevention, but the evidence is considered low to moderate in quality (rated 2/5).

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