Evidence supporting the use of: Sickle-leaf hare's ear
For the health condition: Colds (with fever)

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Sickle-leaf hare's ear (Bupleurum falcatum) has a long history of use in traditional medicine, particularly within Traditional Chinese Medicine (TCM). It is a principal component of the well-known formula "Chai Hu" (Bupleuri Radix), which is used to alleviate symptoms of colds, especially those with fever and alternating chills. The traditional rationale is that Bupleurum is believed to "harmonize" and "release the exterior," concepts rooted in TCM's theoretical framework, rather than biomedical science. Modern scientific studies on Bupleurum falcatum are limited, with most research focusing on its potential anti-inflammatory, antiviral, and immunomodulatory properties. Some in vitro and animal studies suggest the presence of bioactive compounds like saikosaponins may help modulate immune responses and reduce fever. However, robust clinical trials in humans specifically evaluating its efficacy for treating colds with fever are lacking. Most of the support for using Sickle-leaf hare's ear in colds with fever thus comes from centuries of traditional use and TCM literature, rather than from strong scientific validation. While there are promising pharmacological findings, these do not yet provide conclusive evidence for this indication in humans. As such, the evidence is rated as 2, indicating a predominantly traditional basis with some preliminary scientific interest but insufficient clinical data.

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