Bishop's Weed (also known as Ajwain, Trachyspermum ammi) has a long history of use in traditional medicine systems, particularly Ayurveda and Unani, for the treatment of digestive ailments including colic in adults. The seeds contain active compounds such as thymol, which is believed to have carminative, antispasmodic, and antimicrobial properties. Traditional practitioners have recommended Bishop's Weed to relieve abdominal pain, flatulence, and spasmodic disorders of the gastrointestinal tract—symptoms often associated with colic.

However, scientific validation for its efficacy in treating adult colic is limited. Most available studies focus on its general digestive benefits, such as reducing gas or improving intestinal motility, rather than directly addressing adult colic. There are some small-scale animal and in vitro studies suggesting antispasmodic and carminative effects, but robust clinical trials in humans for colic specifically are lacking. Therefore, while Bishop's Weed continues to be used traditionally for colic, its evidence base in modern scientific literature is modest and not definitive.