The use of paw paw (Carica papaya) to support or treat colic in children is primarily rooted in traditional medicine rather than robust scientific evidence. In various African and Caribbean cultures, preparations made from different parts of the paw paw plant—including its leaves, seeds, and unripe fruit—have historically been used to address digestive disorders such as colic, indigestion, and constipation in children. The rationale is often based on the belief that paw paw possesses mild laxative and carminative properties, which can help relieve abdominal discomfort and promote better digestion.

However, scientific studies specifically evaluating the efficacy of paw paw for pediatric colic are lacking. While the fruit contains the enzyme papain, known for aiding digestion and breaking down proteins, there is little direct clinical evidence to confirm its effectiveness for colic in children. Most supportive documentation is anecdotal or drawn from ethnobotanical surveys rather than controlled trials. Furthermore, safety concerns exist regarding the use of certain paw paw preparations in children, as some parts of the plant may be toxic in large amounts.

In summary, the use of paw paw for colic in children is supported by traditional practices, but scientific validation is minimal. Parents and caregivers are advised to consult healthcare professionals before using such remedies, particularly for infants and young children.