Evidence supporting the use of: Bifidobacterium bifidum
For the health condition: Colitis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Bifidobacterium bifidum is one of several probiotic species studied for its potential benefits in managing colitis, particularly inflammatory bowel diseases (IBD) such as ulcerative colitis and Crohn’s disease. Scientific evidence is moderate (rating: 3 out of 5) and primarily comes from preclinical studies, small clinical trials, and meta-analyses of probiotic mixtures rather than B. bifidum alone. Mechanistically, B. bifidum may help by modulating the immune response, strengthening the intestinal barrier, and outcompeting pathogenic bacteria. Some animal studies show that B. bifidum can reduce inflammation and improve histological markers of colitis. In humans, randomized controlled trials using multi-strain probiotic formulations (like VSL#3, which contains B. bifidum among others) have shown benefits in maintaining remission in ulcerative colitis and reducing symptoms, although the specific contribution of B. bifidum is unclear.

Despite these promising results, large-scale, well-controlled trials using B. bifidum as a monotherapy in colitis are lacking. Most evidence supports its use as part of a broader probiotic strategy rather than as a standalone treatment. The overall safety profile is favorable, but guidelines generally recommend probiotics as adjuncts rather than replacements for standard therapy. In summary, while Bifidobacterium bifidum is scientifically validated to some extent for supporting colitis management, especially as part of multi-strain probiotics, the evidence is not robust enough for unequivocal endorsement.

More about Bifidobacterium bifidum
More about Colitis

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Akkermansia muciniphila
algal oil
Aloe vera
anthocyanins
apple
astaxanthin
bacillus clausii
bacillus coagulans
bacillus subtilis
barberry
beta caryophyllene
Bifidobacterium bifidum
Bifidobacterium breve
Bifidobacterium infantis
Bifidobacterium lactis
Bifidobacterium longum
bilberry
bio ecolian (proprietary)
blueberry
bromelain
butyrate triglyceride
cat's claw
Chinese salvia root
chlorella
Coptis chinensis
cowage seed
turmeric
curcumin
fiber blend (proprietary)
flavonols
garlic bulb
ginger
green tea
hemp oil
immunoglobin G
inulin
isomalto-oligosaccharide
L-glutamine
Lactobacillus acidophilus
Lactobacillus brevis
Lactobacillus bulgaricus
Lactobacillus casei
Lactobacillus fermentum
Lactobacillus gasseri
Lactobacillus lactis
Lactobacillus paracasei
lactiplantibacillus plantarum
Lactobacillus reuteri
Lactobacillus rhamnosus
Lactobacillus salivarius
Lactococcus lactis
Lactoferrin
licorice root
N-acetyl-cysteine (NAC)
plantain
pomegranate
prebiotic blend (proprietary)
butyric acid
quercetin
resveratrol
Saccharomyces boulardii
slippery elm bark
specialized pro-resolving mediators (SPMs)
spirulina
streptococcus thermophilus
tributyrin
Triphala
Zinc
xanthium (cockleburs)
blackboard tree
picrorhiza kurroa
Swertia
buckthorn
anemarrhena asphodeloides
Algae
apple cider vinegar
apigenin
anamu
Alchornea
andrographolide
Asteraceae
Acemannan
Amor seco
astragalin
Bifidobacterium
Bifidobacterium adolescentis
Boswellic Acid
bael
Basidiomycota
Boswellia
Baccharoides anthelmintica
Bifidobacterium animalis
back nightshade
bacteria
Bifidobacteria
Bacillus
cactus
Curcuminoid
curcumen
Curcuma
cabbage
Clostridium butyricum
colocynth
diterpenes
Euphorbia
fucoidan
fiber
Frangula
gallic acid
Glycomacropeptides
Guava
Glycyrrhetinic acid
Hedyotis
Helicteres isora
Humic acid
hericium mushroom
Immunoglobulin G
Kefir
Lactobacillus plantarum
Lactobacillus pentosus
Lactobacillus sakei
Lactobacillus kefiri
Lactococcus rhamnosus
Lactococcus casei
Lactobacillus delbrueckii
Lactobacillus johnsonii
Lactobacillus
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polysaccharides
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phlorotannins
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rosmarinic acid
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reed herb
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