Evidence supporting the use of: Bifidobacterium longum
For the health condition: Colitis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Bifidobacterium longum is a probiotic bacterium that has been studied for its potential role in supporting or treating colitis, particularly ulcerative colitis and other forms of inflammatory bowel disease (IBD). Several clinical and preclinical studies provide moderate scientific evidence for its efficacy.

Research indicates that B. longum can modulate the gut microbiota, enhance intestinal barrier function, and reduce inflammation. For example, randomized controlled trials using Bifidobacterium longum in combination with other probiotics (such as in the formulation VSL#3) have shown benefits in reducing disease activity and maintaining remission in ulcerative colitis patients (Gionchetti et al., 2004). Animal studies also demonstrate that B. longum can decrease colonic inflammation and improve mucosal health.

However, most clinical studies use B. longum as part of a multi-strain probiotic, making it difficult to attribute effects to this species alone. Standalone trials of B. longum are fewer, but some show reduced inflammation markers and symptom improvement in colitis models. The safety profile is favorable, and the mechanism involves modulation of immune responses and competition with pathogenic bacteria.

In summary, there is scientific support—though not yet at the highest level of evidence—for using Bifidobacterium longum as an adjunct in managing colitis, especially when combined with other probiotics. More large-scale, strain-specific trials are needed for definitive conclusions.

More about Bifidobacterium longum
More about Colitis

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Akkermansia muciniphila
algal oil
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anthocyanins
apple
astaxanthin
bacillus clausii
bacillus coagulans
bacillus subtilis
barberry
beta caryophyllene
Bifidobacterium bifidum
Bifidobacterium breve
Bifidobacterium infantis
Bifidobacterium lactis
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bilberry
bio ecolian (proprietary)
blueberry
bromelain
butyrate triglyceride
cat's claw
Chinese salvia root
chlorella
Coptis chinensis
cowage seed
turmeric
curcumin
fiber blend (proprietary)
flavonols
garlic bulb
ginger
green tea
hemp oil
immunoglobin G
inulin
isomalto-oligosaccharide
L-glutamine
Lactobacillus acidophilus
Lactobacillus brevis
Lactobacillus bulgaricus
Lactobacillus casei
Lactobacillus fermentum
Lactobacillus gasseri
Lactobacillus lactis
Lactobacillus paracasei
lactiplantibacillus plantarum
Lactobacillus reuteri
Lactobacillus rhamnosus
Lactobacillus salivarius
Lactococcus lactis
Lactoferrin
licorice root
N-acetyl-cysteine (NAC)
plantain
pomegranate
prebiotic blend (proprietary)
butyric acid
quercetin
resveratrol
Saccharomyces boulardii
slippery elm bark
specialized pro-resolving mediators (SPMs)
spirulina
streptococcus thermophilus
tributyrin
Triphala
Zinc
xanthium (cockleburs)
blackboard tree
picrorhiza kurroa
Swertia
buckthorn
anemarrhena asphodeloides
Algae
apple cider vinegar
apigenin
anamu
Alchornea
andrographolide
Asteraceae
Acemannan
Amor seco
astragalin
Bifidobacterium
Bifidobacterium adolescentis
Boswellic Acid
bael
Basidiomycota
Boswellia
Baccharoides anthelmintica
Bifidobacterium animalis
back nightshade
bacteria
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cactus
Curcuminoid
curcumen
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cabbage
Clostridium butyricum
colocynth
diterpenes
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Frangula
gallic acid
Glycomacropeptides
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Glycyrrhetinic acid
Hedyotis
Helicteres isora
Humic acid
hericium mushroom
Immunoglobulin G
Kefir
Lactobacillus plantarum
Lactobacillus pentosus
Lactobacillus sakei
Lactobacillus kefiri
Lactococcus rhamnosus
Lactococcus casei
Lactobacillus delbrueckii
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