Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Lactiplantibacillus plantarum has been investigated for its potential benefits in managing colitis, particularly ulcerative colitis and other inflammatory bowel diseases (IBD). Scientific research, including animal models and some human clinical trials, suggests that L. plantarum may help reduce inflammation and restore intestinal barrier function in colitis. Mechanistically, this probiotic is known to modulate the gut microbiota, enhance mucosal immunity, inhibit pro-inflammatory cytokines like TNF-α and IL-6, and strengthen tight junction proteins in the gut lining.

Several animal studies have shown that administration of L. plantarum can attenuate colonic inflammation, decrease disease activity, and improve histopathological scores. A few small human studies have explored multi-strain probiotic formulations containing L. plantarum in mild to moderate ulcerative colitis, reporting modest improvements in symptoms and inflammatory markers, although results are not uniformly positive and large, high-quality randomized controlled trials are lacking. Current guidelines do not universally recommend L. plantarum as a first-line therapy, but it is considered a promising adjunct. Its safety profile is generally favorable.

In summary, there is scientific validation for the use of L. plantarum in supporting colitis, with an evidence rating of 3/5 due to positive preclinical studies and early clinical data, but more robust and large-scale human trials are needed to confirm efficacy and establish clear therapeutic guidelines.

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