Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactococcus casei is a probiotic bacterium that has been investigated for its potential benefits in managing colitis, particularly inflammatory bowel diseases (IBD) such as ulcerative colitis. Scientific interest in L. casei stems from its immunomodulatory effects and its potential to restore gut microbiota balance. Several animal studies have demonstrated that administration of L. casei can reduce inflammation, decrease disease activity, and ameliorate colonic damage in chemically-induced colitis models (e.g., DSS-induced colitis in mice). These effects are attributed to its ability to modulate cytokine production, enhance epithelial barrier function, and suppress pro-inflammatory pathways.

However, clinical evidence in humans is limited. A few small clinical trials and pilot studies have examined the efficacy of L. casei (often as part of multi-strain probiotic formulations) in patients with ulcerative colitis. Results suggest some potential benefit in maintaining remission or reducing relapse rates, but findings are inconsistent and studies are generally underpowered or lack proper controls. Major clinical guidelines do not currently recommend L. casei as a standard treatment for colitis due to insufficient high-quality evidence.

In summary, while there are plausible mechanisms and promising preclinical data, the clinical evidence is not robust. The rating of 2 reflects preliminary scientific support, but further larger and well-controlled human trials are needed to establish its efficacy for colitis.

More about Lactococcus casei
More about Colitis

Other ingredients used for Colitis

Acemannan
Akkermansia muciniphila
Alchornea
Algae
algal oil
Aloe vera
Amor seco
anamu
andrographolide
anemarrhena asphodeloides
anthocyanins
apigenin
apple
apple cider vinegar
astaxanthin
Asteraceae
astragalin
Baccharoides anthelmintica
Bacillus
bacillus clausii
bacillus coagulans
bacillus subtilis
bacteria
bael
barberry
Basidiomycota
beta caryophyllene
Bifidobacteria
Bifidobacterium
Bifidobacterium adolescentis
Bifidobacterium animalis
Bifidobacterium bifidum
Bifidobacterium breve
Bifidobacterium infantis
Bifidobacterium lactis
Bifidobacterium longum
bilberry
bio ecolian (proprietary)
black nightshade
blackboard tree
blueberry
Boswellia
Boswellic Acid
bromelain
buckthorn
butyrate triglyceride
butyric acid
cabbage
cactus
cat's claw
Chinese salvia root
chlorella
Clostridium butyricum
colocynth
Coptis chinensis
cowage seed
Curcuma
curcumen
curcumin
Curcuminoid
diterpenes
Euphorbia
fiber
fiber blend (proprietary)
flavonols
Frangula
fucoidan
gallic acid
garlic bulb
ginger
Glycomacropeptides
Glycyrrhetinic acid
green tea
Guava
Hedyotis
Helicteres isora
hemp oil
hericium mushroom
Humic acid
immunoglobin G
Immunoglobulin G
inulin
isomalto-oligosaccharide
Kefir
L-glutamine
L. lactis
lactiplantibacillus plantarum
Lactobacillus
Lactobacillus acidophilus
Lactobacillus brevis
Lactobacillus bulgaricus
Lactobacillus casei
Lactobacillus delbrueckii
Lactobacillus fermentum
Lactobacillus gasseri
Lactobacillus johnsonii
Lactobacillus kefiri
Lactobacillus lactis
Lactobacillus paracasei
Lactobacillus pentosus
Lactobacillus plantarum
Lactobacillus reuteri
Lactobacillus rhamnosus
Lactobacillus sakei
Lactobacillus salivarius
Lactococcus casei
Lactococcus lactis
Lactococcus rhamnosus
Lactoferrin
licorice root
Mucilage
N-acetyl-cysteine (NAC)
Nimbidin
Oligosaccharides
Osthole
Oxymatrine
Patrinia
Pediococcus acidilactici
Peptides
phlorotannins
picrorhiza kurroa
Plantago
plantain
polysaccharides
pomegranate
prebiotic blend (proprietary)
probiotics
Propionibacterium freudenreichii
quercetin
resveratrol
Rhus coriaria
rosmarinic acid
Saccharomyces boulardii
Scabrous Gentian
Slippery Elm
slippery elm bark
specialized pro-resolving mediators (SPMs)
spirulina
streptococcus thermophilus
Swertia
Tayuya
Trametes
tributyrin
Triphala
Triterpenes
turmeric
Varuna
xanthium (cockleburs)
Zinc

Other health conditions supported by Lactococcus casei

Cancer Treatment (reducing side effects)
Colitis
Diarrhea
Infection (bacterial)
Inflammatory Bowel Disorders
Irritable Bowel Syndrome

Products containing Lactococcus casei

We currently have no products on Vitabase that contain this ingredient.