Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Pediococcus acidilactici is a lactic acid bacterium increasingly investigated for its potential probiotic benefits, including in gastrointestinal disorders such as colitis. Several preclinical studies (primarily in animal models) have demonstrated that P. acidilactici may help alleviate colitis symptoms. These studies suggest that the bacterium can modulate the gut microbiota, enhance intestinal barrier integrity, and reduce pro-inflammatory cytokines (such as TNF-α and IL-6) in chemically induced colitis models. For example, mouse studies have found that administering P. acidilactici lessened colonic inflammation and improved clinical scores of colitis induced by agents like dextran sulfate sodium (DSS).

However, there is a lack of robust human clinical trial data directly supporting the efficacy of P. acidilactici for the treatment or management of colitis (including ulcerative colitis or Crohn’s disease). Most evidence is preclinical, and while promising, extrapolation to human disease is premature. Systematic reviews on probiotics for colitis generally focus on other strains (e.g., Lactobacillus, Bifidobacterium), with P. acidilactici rarely featured.

In summary, the use of Pediococcus acidilactici for colitis is justified by emerging scientific (preclinical) evidence, but high-quality clinical trials in humans are needed. The current evidence strength is rated 2/5, indicating preliminary but not definitive support.

More about Pediococcus acidilactici
More about Colitis

Other ingredients used for Colitis

Acemannan
Akkermansia muciniphila
Alchornea
Algae
algal oil
Aloe vera
Amor seco
anamu
andrographolide
anemarrhena asphodeloides
anthocyanins
apigenin
apple
apple cider vinegar
astaxanthin
Asteraceae
astragalin
Baccharoides anthelmintica
Bacillus
bacillus clausii
bacillus coagulans
bacillus subtilis
bacteria
bael
barberry
Basidiomycota
beta caryophyllene
Bifidobacteria
Bifidobacterium
Bifidobacterium adolescentis
Bifidobacterium animalis
Bifidobacterium bifidum
Bifidobacterium breve
Bifidobacterium infantis
Bifidobacterium lactis
Bifidobacterium longum
bilberry
bio ecolian (proprietary)
black nightshade
blackboard tree
blueberry
Boswellia
Boswellic Acid
bromelain
buckthorn
butyrate triglyceride
butyric acid
cabbage
cactus
cat's claw
Chinese salvia root
chlorella
Clostridium butyricum
colocynth
Coptis chinensis
cowage seed
Curcuma
curcumen
curcumin
Curcuminoid
diterpenes
Euphorbia
fiber
fiber blend (proprietary)
flavonols
Frangula
fucoidan
gallic acid
garlic bulb
ginger
Glycomacropeptides
Glycyrrhetinic acid
green tea
Guava
Hedyotis
Helicteres isora
hemp oil
hericium mushroom
Humic acid
immunoglobin G
Immunoglobulin G
inulin
isomalto-oligosaccharide
Kefir
L-glutamine
L. lactis
lactiplantibacillus plantarum
Lactobacillus
Lactobacillus acidophilus
Lactobacillus brevis
Lactobacillus bulgaricus
Lactobacillus casei
Lactobacillus delbrueckii
Lactobacillus fermentum
Lactobacillus gasseri
Lactobacillus johnsonii
Lactobacillus kefiri
Lactobacillus lactis
Lactobacillus paracasei
Lactobacillus pentosus
Lactobacillus plantarum
Lactobacillus reuteri
Lactobacillus rhamnosus
Lactobacillus sakei
Lactobacillus salivarius
Lactococcus casei
Lactococcus lactis
Lactococcus rhamnosus
Lactoferrin
licorice root
Mucilage
N-acetyl-cysteine (NAC)
Nimbidin
Oligosaccharides
Osthole
Oxymatrine
Patrinia
Pediococcus acidilactici
Peptides
phlorotannins
picrorhiza kurroa
Plantago
plantain
polysaccharides
pomegranate
prebiotic blend (proprietary)
probiotics
Propionibacterium freudenreichii
quercetin
resveratrol
Rhus coriaria
rosmarinic acid
Saccharomyces boulardii
Scabrous Gentian
Slippery Elm
slippery elm bark
specialized pro-resolving mediators (SPMs)
spirulina
streptococcus thermophilus
Swertia
Tayuya
Trametes
tributyrin
Triphala
Triterpenes
turmeric
Varuna
xanthium (cockleburs)
Zinc

Other health conditions supported by Pediococcus acidilactici

Antibiotics (side effects of)
Colitis
Diarrhea
Infection
Infection (bacterial)
Inflammatory Bowel Disorders
Irritable Bowel Syndrome

Products containing Pediococcus acidilactici

We currently have no products on Vitabase that contain this ingredient.