Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Quercetin is a plant flavonoid found in various fruits and vegetables, and its use in colitis is primarily supported by preclinical scientific evidence. Several animal studies have demonstrated that quercetin possesses anti-inflammatory, antioxidant, and immunomodulatory properties, which may help ameliorate colonic inflammation in models of ulcerative colitis and Crohn’s disease. Mechanistically, quercetin appears to inhibit the production of pro-inflammatory cytokines (such as TNF-α and IL-6), reduce oxidative stress, and modulate the gut microbiota, all of which are implicated in colitis pathogenesis.

For example, a 2012 study in "Inflammatory Bowel Diseases" showed that quercetin supplementation reduced colonic damage and inflammation in a mouse model of DSS-induced colitis. Other studies have reported similar protective effects, including improvements in intestinal barrier function and reduction in inflammatory infiltrates. However, while these results are promising, well-designed human clinical trials are lacking. As of 2024, only limited and preliminary human evidence exists, and quercetin is not an established or guideline-recommended therapy for colitis.

In summary, quercetin's use in colitis is based on encouraging animal and laboratory data, but robust clinical trials in humans are needed. Therefore, while its scientific rationale is plausible, the overall strength of evidence is modest (rated 2/5), and it should not replace standard medical treatments.

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